2009 H1N1 fatalities: the New Mexico experience

Journal of Forensic Sciences
Erin G BrooksK B Nolte

Abstract

Histopathologic features of New Mexico 2009 H1N1 fatalities have not been representative of those reported nationwide. We retrospectively reviewed medical records of all New Mexico 2009 pandemic influenza A (pH1N1) fatalities (n = 50). In cases in which autopsy was performed (n = 12), histologic sections and culture results were examined. In contrast to previously published studies, the majority of our fatalities did not have diffuse alveolar damage (DAD) (2/12; 16.7%). Common findings included pulmonary interstitial inflammation and edema, tracheobronchitis, and pneumonia. Two cases had significant extra-pulmonary manifestations: myocarditis and cerebral edema with herniation. The majority had a rapid disease course: range from 1 to 12 days (median, 2 days), and Native Americans were disproportionately represented among fatalities. These findings suggest that New Mexico H1N1 fatalities generally did not survive long enough to develop the classic picture of DAD. Pathologists should be aware that H1N1 may cause extra-pulmonary pathology and perform postmortem cultures and histologic sampling accordingly.

References

Aug 15, 2000·American Journal of Clinical Pathology·J GuarnerS R Zaki
Jan 11, 2000·The American Journal of Forensic Medicine and Pathology·K B NolteS R Zaki
Mar 12, 1959·The New England Journal of Medicine·R OSEASOHNM KAJI
Apr 14, 2004·Emerging Infectious Diseases·Mitchell I WolfeSteven S Yoon
Jun 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeannette GuarnerSherif R Zaki
Nov 28, 2007·Annual Review of Pathology·Jeffery K Taubenberger, David M Morens
Oct 14, 2009·JAMA : the Journal of the American Medical Association·Anand KumarUNKNOWN Canadian Critical Care Trials Group H1N1 Collaborative
Oct 31, 2009·American Journal of Respiratory and Critical Care Medicine·Thais MauadPaulo H N Saldiva
Nov 6, 2009·JAMA : the Journal of the American Medical Association·Janice K LouieUNKNOWN California Pandemic (H1N1) Working Group
Nov 13, 2009·The New England Journal of Medicine·M Virgilia Soto-AbrahamFrancisco Navarro-Reynoso
Jan 14, 2010·Current Opinion in Pediatrics·Natasha B Halasa
Feb 9, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kelvin K W ToKwok-Yung Yuen
Feb 16, 2010·Journal of the American College of Cardiology·András BratincsákChristopher R Cannavino
May 7, 2010·The New England Journal of Medicine·Edgar BautistaKarl G Nicholson
May 29, 2010·The American Journal of Pathology·Wun-Ju ShiehSherif R Zaki
Jun 17, 2010·American Journal of Clinical Pathology·Paul W HarmsJeffrey M Jentzen

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Citations

Jul 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tomer HertzLawrence Corey
Jan 11, 2013·Influenza Research and Treatment·Akira UkimuraYumiko Kanzaki

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