2018 update of the APLAR recommendations for treatment of rheumatoid arthritis

International Journal of Rheumatic Diseases
Chak Sing LauSwan Sim Yeap

Abstract

To update recommendations based on current best evidence concerning the treatment of rheumatoid arthritis (RA), focusing particularly on the role of targeted therapies, to inform clinicians on new developments that will impact their current practice. A search of relevant literature from 2014 to 2016 concerning targeted therapies in RA was conducted. The RA Update Working Group evaluated the evidence and proposed updated recommendations using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach, to describe the quality of evidence and strength of recommendations. Recommendations were finalized through consensus using the Delphi technique. This update provides 16 RA treatment recommendations based on current best evidence and expert clinical opinion. Recommendations 1-3 deal with the use of conventional synthetic disease-modifying antirheumatic drugs. The next three recommendations (4-6) cover the need for screening and management of infections and comorbid conditions prior to starting targeted therapy, while the following seven recommendations focus on use of these agents. We address choice of targeted therapy, switch, tapering and discontinuation. The last three recommendations elaborate on t...Continue Reading

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Citations

Sep 3, 2020·Clinical Rheumatology·Valeria ValerioInés Colmegna
Sep 6, 2019·Clinical Rheumatology·Carmen Tze Kwan HoUNKNOWN Hong Kong Society of Rheumatology
Aug 22, 2020·Journal of Pain Research·Kok Yuen HoErnest Choy
Apr 4, 2021·Pharmaceutics·Margarida Ferreira-SilvaMaria Luísa Corvo
Apr 4, 2021·International Journal of Molecular Sciences·Katarzyna Romanowska-PróchnickaDariusz Szukiewicz
Apr 4, 2021·Medicina·Xiangyu ZhaoYoung-Ok Son
May 1, 2021·Pharmacology Research & Perspectives·Junko ToyoshimaTetsuya Nishimura
Feb 3, 2021·Chinese Medical Journal·Rong LiLi-Yun Zhang
Jul 1, 2021·Military Medicine·Choon-Guan Chua, Bernard Yu-Hor Thong
Aug 20, 2021·Annals of the Rheumatic Diseases·György NagyJacob M van Laar
Sep 3, 2021·Biological & Pharmaceutical Bulletin·Takanori InagakiRyohkan Funakoshi
Dec 12, 2020·International Immunopharmacology·Chang-Hong LiJin-Xia Zhao
Jan 20, 2022·International Journal of Rheumatic Diseases·Sakir AhmedLisa Traboco

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