2019 FDA TIDES (Peptides and Oligonucleotides) Harvest

Pharmaceuticals
Danah Al ShaerBeatriz G de la Torre

Abstract

2019 has been an excellent year in terms of peptides and oligonucleotides (TIDES) approved by the FDA. Despite the drop in the number of total drugs approved by the FDA in 2019 in comparison with 2018 (48 vs. 59), the total number of TIDES authorized increased (seven vs. three). Year after year, TIDES are increasingly present in therapy, as imaging agents, theragnostic and constituent moieties of other complex drugs, such as antibody drug conjugates. This means a consolidation of these kinds of drugs in the pharmaceutical arena, paving the way in the coming years for the approval of others for diverse medical indications. Here the TIDES approved in 2019 are analyzed in terms of chemical structure, medical target, mode of action, and adverse effects.

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Citations

Jun 17, 2020·Nucleic Acids Research·Arwaf S AlharbiMichael P Gantier
May 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Beatriz G de la Torre, Fernando Albericio
Jun 27, 2020·International Journal of Molecular Sciences·Mahama AlhassanBeatriz G de la Torre
Jan 5, 2021·Organic Letters·Yves YeboueThomas-Xavier Métro
Mar 7, 2021·Pharmaceuticals·Othman Al MusaimiBeatriz G de la Torre
Feb 20, 2021·Drug Design, Development and Therapy·Mohamad MoussaAthanasios Dellis
Nov 25, 2020·Organic Letters·Amit ChakrabortyBeatriz G de la Torre

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Methods Mentioned

BETA
antisense oligonucleotide

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