20(s)-Protopanaxadiol (PPD) increases the radiotherapy sensitivity of laryngeal carcinoma

Food & Function
Bo TengChunhui Yi

Abstract

Laryngeal carcinoma (LC) is one of the most prevalent malignant tumors in the head and neck area. Due to its high morbidity and mortality, LC poses a serious threat to human life and health. Even with surgical removal, some patients were not sensitive to radiotherapy or experienced transfer or recurrence. 20(s)-Protopanaxadiol (PPD), a natural product from Panax ginseng, has been reported to have cytotoxic effects against several cancer cell lines. However, whether it can improve the radiation sensitivity and the underlying mechanism of PPD's sensitization effect is still unknown. Herein, from in vitro and in vivo experiments, we found that the combination of PPD and radiation not only significantly inhibited proliferation and induced apoptosis, but also suppressed the tumor growth in mouse models. These findings confirmed the role of PPD in enhancing the sensitivity of radiotherapy. Moreover, our work showed that the expression levels of mTOR and its downstream effectors decreased remarkably after PPD addition when compared to radiation only. This result suggested that PPD's excellent synergistic effects with radiation might be associated with the down-regulation of the mTOR signaling pathway in Hep-2 cells.

References

Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·T W SedlakS J Korsmeyer
Apr 16, 1998·The Journal of Biological Chemistry·E P RogakouW M Bonner
Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Sep 23, 2008·Phytotherapy Research : PTR·Shaival Kamalaksha RaoB Nageshwara Rao
Dec 4, 2008·The American Journal of Chinese Medicine·Chong-Zhi Wang, Chun-Su Yuan
Dec 22, 2009·World Journal of Surgical Oncology·Kuauhyama Luna-OrtizVeronica Villavicencio-Valencia
Sep 29, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Marco LionelloGino Marioni
Jan 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Filip JankuRazelle Kurzrock
Jun 14, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Roberto SantoroOreste Gallo
Sep 24, 2013·Cancer Treatment Reviews·Susan HeaveyKathy Gately
Sep 26, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Marco LionelloG Marioni
Feb 1, 2014·Nature Reviews. Drug Discovery·David A Fruman, Christian Rommel
Oct 5, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Andrea LovatoStella Blandamura
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 28, 2016·Oncotarget·Darío García-CarracedoJuana María García-Pedrero
Mar 25, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo TengBinfeng Lu
Jul 16, 2017·Scientific Reports·Katarzyna KiwerskaMaciej Giefing

❮ Previous
Next ❯

Citations

Aug 14, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Guan-Jiang Huang, Bei-Bei Yang

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
flow cytometry
xenograft
xenografts
PCR

Software Mentioned

Image
Pro Plus
SPSS

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Related Papers

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Bo TengBinfeng Lu
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
Tingyan LiuWenyue Ji
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
Junhui ZhangMingmin Dong
© 2022 Meta ULC. All rights reserved