PMID: 9433901Jan 20, 1998Paper

2,2'-Azobis (4-methoxy-2,4-dimethylvaleronitrile), a new lipid-soluble azo initiator: application to oxidations of lipids and low-density lipoprotein in solution and in aqueous dispersions

Free Radical Biology & Medicine
Noriko NoguchiE Niki

Abstract

Both hydrophilic and hydrophobic azo radical initiators are useful for in vitro studies on lipid peroxidation and its inhibition by antioxidants. In the present study, a new lipophilic azo compound, 2,2'-azobis(4-methoxy-2,4-dimethylvaleronitrile) (MeO-AMVN), was introduced and its action as an initiator of lipid peroxidation was examined. MeO-AMVN decomposed about 15 times as fast as 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN), a widely used lipophilic azo initiator, and MeO-AMVN-initiated free radical-mediated peroxidations of lipids in organic solution and in micelles, membranes, and low-density lipoprotein in aqueous dispersions with much smaller concentration than AMVN. The rate of chain initiation by MeO-AMVN varied significantly with the medium and decreased with increasing viscosity of the medium. The advantage and cautions for using MeO-AMVN as a lipophilic radical source have been discussed and it has been concluded that MeO-AMVN, when properly used, is a useful radical initiator of lipid peroxidations especially in micelles, membranes, and lipoproteins.

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Citations

Jun 18, 2016·Oxidative Medicine and Cellular Longevity·Alexey V LokhmatikovArmen Y Mulkidjanian
Dec 13, 2019·Oxidative Medicine and Cellular Longevity·Konstantin G LyamzaevBoris V Chernyak
Oct 25, 2002·Redox Report : Communications in Free Radical Research·L RackovaM Majekova
Dec 19, 2014·Biochemistry. Biokhimii︠a︡·A V LokhmatikovA Y Mulkidjanian
Sep 7, 2016·International Journal of Molecular Sciences·Kun ChunSang-Han Lee
Feb 12, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Helena TauteAnabella R M Gaspar
Mar 10, 2001·Antioxidants & Redox Signaling·K MiyauchiE Niki
Apr 18, 2015·Chembiochem : a European Journal of Chemical Biology·Michio IwaokaK Indira Priyadarsini
Feb 23, 2010·Journal of Medicinal Food·Dragana D Cetojević-SiminBratislav T Stojiljković
Nov 10, 2016·International Journal of Molecular Sciences·Md Badrul AlamSang-Han Lee
Mar 22, 2019·Molecular and Cellular Biochemistry·Ningjian LiangDavid D Kitts
Oct 8, 2004·Journal of Biochemistry and Molecular Biology·Robert Antoni OlekJedrzej Antosiewicz
Jul 14, 2001·Redox Report : Communications in Free Radical Research·Y Okada, H Okajima
Feb 24, 2010·The Journal of Physical Chemistry. B·Monica MoscaLuigi Ambrosone
Oct 26, 2001·Free Radical Biology & Medicine·G AldiniN I Krinsky
Jan 11, 2003·Free Radical Biology & Medicine·Ayelet M Samuni, Yechezkel Barenholz
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May 24, 2003·Biochemical and Biophysical Research Communications·Yasukazu YoshidaEtsuo Niki
Jul 21, 2006·Archives of Biochemistry and Biophysics·Melody S Calla, Sean M Lynch
Oct 20, 2015·Journal of Agricultural and Food Chemistry·Erwann DurandRyan J Elias

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