22-Oxocholestane oximes as potential anti-inflammatory drug candidates

European Journal of Medicinal Chemistry
Reyna Zeferino-DiazMaría A Fernández-Herrera

Abstract

22-Oxocholestanes bearing the oxime functionality in the side chain have been synthesized from diosgenin and evaluated in vivo as anti-inflammatory agents in an acute inflammation mouse ear model, against the commercial glucocorticoid dexamethasone. The final compounds were all regioselectively obtained with an E configuration at the oxime double bond. The title compounds reduced ear-induced inflammation and edema. The most active oximes repressed the expression of proinflammatory genes TNF-α, COX-2, and IL-6; including macrophage migration inhibitory factor. Overall, our data suggest that 22-oxocholestane oximes exert a strong in vivo anti-inflammatory activity.

Citations

Jun 3, 2021·Biomolecules·Igor A SchepetkinMark T Quinn
Jul 30, 2021·Bioorganic Chemistry·J Ciciolil Hilario-MartínezMaría A Fernández-Herrera
Apr 16, 2020·ACS Medicinal Chemistry Letters·Yixiao SunGangqiang Yang
Oct 8, 2021·Organic & Biomolecular Chemistry·Jiabin ShenPengfei Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

The Journal of Steroid Biochemistry and Molecular Biology
Monika SinghDnyaneshwar U Bawankule
Steroids
Reyna Zeferino-DiazMaría A Fernández-Herrera
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Luis Sánchez-SánchezJesús Sandoval-Ramírez
© 2022 Meta ULC. All rights reserved