223 Ra-Dichloride in castration-resistant metastatic prostate cancer: improving outcomes and identifying predictors of survival in clinical practice

European Journal of Nuclear Medicine and Molecular Imaging
Sabina DizdarevicAngus Robinson

Abstract

We first assessed whether the pattern of referrals to a nuclear medicine clinic improved as experience with 223Ra-dichloride increased, and whether referral patterns affected patient outcomes, and second assessed the value of bone scintigraphy, total alkaline phosphatase (tALP) and lymphadenopathy as prognostic factors in patients receiving 223Ra-dichloride. A total of 57 patients eligible to receive 223Ra-dichloride over a 2-year period (March 2014 to March 2016) were retrospectively assessed and prospectively followed (median follow up 298 days). 223Ra-Dichloride was administered at 4-week intervals for a maximum of six injections. The numbers of patients in years 1 and 2 referred in relation to extent of bone disease (EOBD) category and overall survival (OS) were determined. The prognostic factors EOBD category, baseline tALP (tALPBL), tALP response, greatest percentage reduction in tALP from baseline in any treatment cycle (ALPmax; among patients with elevated ALPBL), and the presence of lymphadenopathy were assessed as predictors of OS. The proportion of patients with EOBD1 was higher in year 2 than in year 1 (29% and 4%, respectively), and in year 2 there was a lower rate of symptomatic skeleton-related events, a higher p...Continue Reading

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Citations

Mar 26, 2019·Nuclear Medicine Communications·Valentin RoqueElizabete Carolino
Sep 1, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Sabina DizdarevicSobhan Vinjamuri
Mar 24, 2020·Cancer Biotherapy & Radiopharmaceuticals·Hossein Jadvar
Nov 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Narges K TafreshiDavid L Morse
Aug 19, 2020·Journal of Clinical Medicine·Reyhaneh Manafi-FaridMohsen Beheshti
Mar 10, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Maarten J van der DoelenAnders Ullén

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