223 Ra-dichloride therapy of bone metastasis: optimization of SPECT images for quantification

EJNMMI Research
Nadia BenabdallahAurélie Desbrée

Abstract

223Ra imaging is crucial to evaluate the successfulness of the therapy of bone metastasis of castration-resistant prostate cancer (CRPC). The goals of this study were to establish a quantitative tomographic 223Ra imaging protocol with clinically achievable conditions, as well as to investigate its usefulness and limitations. We performed several experiments using the Infinia Hawkeye 4 gamma camera (GE) and physical phantoms in order to assess the optimal image acquisition and reconstruction parameters, such as the windows setting, as well as the iteration number and filter of the reconstruction algorithm. Then, based on the MIRD pamphlet 23, we used a NEMA phantom and an anthropomorphic TORSO® phantom to calibrate the gamma camera and investigate the accuracy of quantification. Experiences showed that the 85 keV ± 20%, 154 keV ± 10%, and 270 keV ± 10% energy windows are the most suitable for 223Ra imaging. The study with the NEMA phantom showed that the OSEM algorithm with 2 iterations, 10 subsets, and the Butterworth filter offered the best compromise between contrast and noise. Moreover, the calibration factors for different sphere sizes (26.5 ml, 11.5 ml, and 5.6 ml) were constant for 223Ra concentrations ranging between 6.5...Continue Reading

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Citations

Mar 18, 2020·Cancer Biotherapy & Radiopharmaceuticals·Diane S AbouDaniel L J Thorek
Feb 25, 2020·Physics in Medicine and Biology·Johan GustafssonPablo Mínguez
Jun 26, 2020·Frontiers in Oncology·Diane AbouDaniel L J Thorek
Feb 20, 2020·Cancer Biotherapy & Radiopharmaceuticals·Janina Baranowska-KortylewiczDon W Coulter
May 21, 2020·Cancer Biotherapy & Radiopharmaceuticals·Iain MurrayGlenn D Flux

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