22q11.2 deletion syndrome: are motor deficits more than expected for IQ level?

The Journal of Pediatrics
Nancy J RoizenWendy R Kates

Abstract

To examine motor function in children with 22q11.2 deletion syndrome (22q11.2) and a Full Scale IQ (FSIQ) comparable control group. This study was part of a prospective study of neuropsychological function in children 9 to 15 years of age with 22q11.2 and community control subjects and included children from these two populations with comparable FSIQs. Verbal IQs on the WISC-R for 40 children with 22q11.2 (88.4) and 24 community control subjects (87.2) were not different (P=.563). However, the performance IQs were (22q11.2; 81.1 vs community controls; 89.3; P<.001). On the Visual Motor Inventory, there was no difference between the standard scores of the two groups (22q11.2; 93.0 vs community control subjects; 98.1; P=.336) but on the motor coordination part of the Visual Motor Inventory, the scores of the 22q11.2 deletion syndrome group were lower (77.2 vs 89.3; P=.002). On the general neurologic examination (P=.906), the tone examination (P=.705), and the ball skills part of the Motor Battery, (P=.378), there were no differences. However, on the axial stability part of the Motor Battery, the children with 22q11.2 exhibited less good balance (P=.026). School-aged children with 22q11.2 have specific motor deficits in axial stab...Continue Reading

References

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Citations

Jun 30, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Nancy J ButcherAnne S Bassett
Jul 3, 2015·Journal of Neurodevelopmental Disorders·Alina GunaAnne S Bassett
Feb 17, 2015·American Journal of Medical Genetics. Part a·Erik BootAnne S Bassett
Oct 27, 2018·American Journal of Medical Genetics. Part a·Sarah E HopkinsDonna M McDonald-McGinn
Jan 13, 2019·American Journal of Medical Genetics. Part a·Annelore WillaertGreet Hens
Aug 23, 2016·Psychiatric Genetics·Livia CasarelliAugusto Pasini
Mar 17, 2018·AJNR. American Journal of Neuroradiology·E VerheijH G X M Thomeer
Jun 12, 2019·Journal of Neurodevelopmental Disorders·Adam C CunninghamMarianne B M van den Bree
Nov 20, 2019·Psychological Medicine·Adam C CunninghamMarianne B M van den Bree
Jun 4, 2021·Current Opinion in Genetics & Development·Michael Mortillo, Jennifer G Mulle

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22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.

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