22q11.2 Deletion Syndrome Is Associated With Impaired Auditory Steady-State Gamma Response

Schizophrenia Bulletin
Kit Melissa LarsenHartwig Roman Siebner

Abstract

The 22q11.2 deletion syndrome confers a markedly increased risk for schizophrenia. 22q11.2 deletion carriers without manifest psychotic disorder offer the possibility to identify functional abnormalities that precede clinical onset. Since schizophrenia is associated with a reduced cortical gamma response to auditory stimulation at 40 Hz, we hypothesized that the 40 Hz auditory steady-state response (ASSR) may be attenuated in nonpsychotic individuals with a 22q11.2 deletion. Eighteen young nonpsychotic 22q11.2 deletion carriers and a control group of 27 noncarriers with comparable age range (12-25 years) and sex ratio underwent 128-channel EEG. We recorded the cortical ASSR to a 40 Hz train of clicks, given either at a regular inter-stimulus interval of 25 ms or at irregular intervals jittered between 11 and 37 ms. Healthy noncarriers expressed a stable ASSR to regular but not in the irregular 40 Hz click stimulation. Both gamma power and inter-trial phase coherence of the ASSR were markedly reduced in the 22q11.2 deletion group. The ability to phase lock cortical gamma activity to regular auditory 40 Hz stimulation correlated with the individual expression of negative symptoms in deletion carriers (ρ = -0.487, P = .041). Nonps...Continue Reading

References

Jan 1, 1991·Acta Oto-laryngologica. Supplementum·G PlourdeT W Picton
Jan 6, 1999·Archives of Disease in Childhood·J GoodshipC Wren
Nov 24, 1999·Archives of General Psychiatry·J S KwonR W McCarley
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·R D TraubM A Whittington
Jan 23, 2004·Archives of Disease in Childhood·S OskarsdóttirA Fasth
Aug 27, 2004·Schizophrenia Research·L Elliot HongGunvant K Thaker
Mar 3, 2005·The American Journal of Psychiatry·Matthew P SymondLeanne M Williams
Apr 2, 2005·Nature Reviews. Neuroscience·David A LewisDavid W Volk
Jul 20, 2005·The Journal of Pediatrics·Nathaniel H Robin, Robert J Shprintzen
Dec 1, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Donald C RojasMartin L Reite
Dec 21, 2006·Nature Reviews. Neuroscience·Marlene BartosPeter Jonas
Apr 11, 2008·Biological Psychiatry·Kevin M SpencerRobert W McCarley
Sep 23, 2008·Human Molecular Genetics·Anne S BassettStephen W Scherer
Apr 18, 2009·NeuroImage·G P KrishnanB F O'Donnell
Apr 28, 2009·Nature·Vikaas S SohalKarl Deisseroth
Jul 3, 2009·Nature·UNKNOWN International Schizophrenia ConsortiumPamela Sklar
Jul 22, 2009·BMC Neuroscience·Kevin M SpencerRobert W McCarley
Jan 19, 2010·Trends in Cognitive Sciences·Peter J UhlhaasWolf Singer
Mar 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jong H YoonCameron S Carter
Apr 27, 2010·Harvard Review of Psychiatry·Tsung-Ung W WooRobert W McCarley
May 21, 2010·Nature Reviews. Neuroscience·Maria KarayiorgouJoseph A Gogos
Oct 15, 2010·Psychological Medicine·T K LarsenT McGlashan
Jan 22, 2011·Computational Intelligence and Neuroscience·Robert OostenveldJan-Mathijs Schoffelen
Sep 10, 2011·Neural Plasticity·Guillermo Gonzalez-BurgosDavid A Lewis
Mar 3, 2012·Biological Psychiatry·Vikaas S Sohal
Mar 13, 2012·The American Journal of Psychiatry·Wenche Ten Velden HegelstadThomas McGlashan
Mar 27, 2012·Annual Review of Neuroscience·György Buzsáki, Xiao-Jing Wang
Jul 31, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Erol Başar
Sep 3, 2013·Biological Psychiatry·Rachel K JonasCarrie E Bearden
Dec 20, 2013·Neuropsychiatric Disease and Treatment·Chiara SquarcioneMassimo Biondi
Mar 1, 2014·The American Journal of Psychiatry·Maude SchneiderUNKNOWN International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome
Jul 16, 2014·Frontiers in Neuroscience·Kazuhito Nakao, Kazu Nakazawa
Nov 8, 2014·NeuroImage. Clinical·Anouk MarsmanHilleke E Hulshoff Pol
Jan 4, 2015·The International Journal of Neuropsychopharmacology·Elyse M SullivanPatricio O'Donnell

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Citations

Dec 9, 2017·Brain Topography·Sigita MelynyteInga Griskova-Bulanova
Mar 12, 2019·Human Brain Mapping·Giovanni PellegrinoHartwig Roman Siebner
Aug 24, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daisuke KoshiyamaGregory A Light
Nov 18, 2018·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lucy GaoRaquel E Gur
Jan 9, 2019·Frontiers in Neurology·Giovanni PellegrinoGiovanni Assenza
Jun 27, 2020·Frontiers in Psychiatry·Sokichi HondaTakuma Mihara
Dec 20, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Daisuke KoshiyamaGregory A Light
Dec 18, 2021·NeuroImage·Giovanni PellegrinoEliane Kobayashi

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22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.