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2'3'-cGAMP triggers a STING and NF-κB dependent broad antiviral response in Drosophila

bioRxiv

Nov 27, 2019

Hua CaiJean-Luc Imler

Abstract

We recently reported that an orthologue of STING regulates infection by picorna-like viruses in drosophila. In mammals, STING is activated by the cyclic dinucleotide 2'3'-cGAMP produced by cGAS, which acts as a receptor for cytosolic DNA. Here, we show that injection of flies with 2'3'-...read more

Mentioned in this Paper

Interferons
SiRNA Binding
Injection Procedure
Interferon Regulatory Factors
ATG7 gene
NO STING
Antiviral Therapy
Cyclic Peptides
RNA
Autophagy
32
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2'3'-cGAMP triggers a STING and NF-κB dependent broad antiviral response in Drosophila

bioRxiv

Nov 27, 2019

Hua CaiJean-Luc Imler

DOI: 10.1101/852319

Abstract

We recently reported that an orthologue of STING regulates infection by picorna-like viruses in drosophila. In mammals, STING is activated by the cyclic dinucleotide 2'3'-cGAMP produced by cGAS, which acts as a receptor for cytosolic DNA. Here, we show that injection of flies with 2'3'-...read more

Mentioned in this Paper

Interferons
SiRNA Binding
Injection Procedure
Interferon Regulatory Factors
ATG7 gene
NO STING
Antiviral Therapy
Cyclic Peptides
RNA
Autophagy
32

Similar Papers Found In These Feeds

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