2,3,4',5-Tetrahydroxystilbene-2-O-β-D-glucoside inhibits angiotensin II-induced cardiac fibroblast proliferation via suppression of the reactive oxygen species-extracellular signal-regulated kinase 1/2 pathway

Clinical and Experimental Pharmacology & Physiology
Wei ZhangWeizhong Zhu

Abstract

Cardiac fibroblasts (CF) have direct and potent effects on myocardial remodelling by proliferating, differentiating and secreting extracellular matrix proteins. Prolonged activation of CF leads to cardiac fibrosis and reduces myocardial contractile function. In previous studies we showed that 2,3,4',5-tetrahydroxystilbene-2-O-β-d-glucoside (TSG) exerts cardiac protection, but the mechanism involved remains unclear. The aim of the present study was to evaluate the effects of TSG on angiotensin (Ang) II-induced CF proliferation and to explore the underlying intracellular mechanisms. Angiotensin II (100 nmol/L)-induced proliferation of rat neonatal fibroblasts was significantly inhibited by TSG (3-100 μmol/L), as evidenced by investigations of cell numbers and 5-bromodeoxyuridine (BrdU) incorporation. In addition, 30 μmol/L TSG suppressed AngII-induced expression of nuclear antigen, matrix metalloproteinase (MMP)-2 and MMP-9. Moreover, TSG attenuated AngII-induced activation of mitogen-activated protein kinase kinase (MEK) and extracellular signal-regulated kinase (ERK) 1/2. Angiotensin II (100 nmol/L)-induced generation of reactive oxygen species (ROS) was reduced by 30 μmol/L TSG, as was H(2) O(2) -induced activation of ERK1/2. ...Continue Reading

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Citations

Jul 8, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G Díaz-ArayaC Muñoz
Nov 20, 2016·Clinical and Experimental Pharmacology & Physiology·Yunxuan ChenWeizhong Zhu
Dec 14, 2018·Oxidative Medicine and Cellular Longevity·Lingling Zhang, Jianzong Chen
Jun 3, 2021·Biology·Nadine BleyStefan Hüttelmaier

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