PMID: 6331096Jan 1, 1984

24-36-Chromosome clones in human malignancies. Cytogenetic interrelationships, clinical significance and patient age

Acta Radiologica. Oncology
B Pedersen


The literature has been reviewed for cases of malignant disease showing cellular clones with 24-36 chromosomes. Such cases are characterized by aggressive disease. Together the clones with 24-36 chromosomes compose a remarkably consistent non-random cytogenetic pattern, which demonstrates that different chromosomes are of different value for cellular survival and clonal propagation. Considering that the tissues of origin are very different (various solid tumours and different leukaemias), the close mutual cytogenetic relationship between the clones indicates that the cytogenetic pattern is tissue non-specific. Karyotypic non-specificity of cells with very different phenotypes is an apparent contradiction, which raises important questions concerning the relation between karyotype and phenotype.


Dec 1, 1979·American Journal of Clinical Pathology·F ShabtaiM Djaldetti
Jun 1, 1983·Cancer Genetics and Cytogenetics·B Pedersen, A M Boesen
Oct 1, 1982·Cancer Genetics and Cytogenetics·G M BrodeurA A Green
Aug 1, 1981·Cancer Genetics and Cytogenetics·S E PetersenU Friedrich
Jan 1, 1981·Human Genetics·N B Atkin, M C Baker


Apr 1, 1991·Cancer Genetics and Cytogenetics·C SreekantaiahA A Sandberg
Apr 1, 1987·Pathology·S TallentsE Januszewicz
Aug 1, 1990·Gynecologic Oncology·C SreekantaiahA A Sandberg
Dec 15, 1984·International Journal of Cancer. Journal International Du Cancer·V Brito-BabapulleD Catovsky

Related Concepts

Clone Cells
Karyotype Determination Procedure
Lymphoid Leukemia
Leukemia, Monocytic, Chronic
Malignant Neoplasms

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