PMID: 9165484Apr 1, 1997Paper

2,4-dichlorophenoxyacetic acid through lactation induces astrogliosis in rat brain

Molecular and Chemical Neuropathology
A BruscoR Duffard

Abstract

Comparison of astroglial immunoreactivity in mesencephalon, cerebellum, and hippocampus of 25-d-old rat pups exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) through the mother's milk was made using a quantitative immunohistochemical analysis. A glial reaction was detected at the level of serotonergic nuclei and extreme astrogliosis in the hippocampus and cerebellum. A quantitative analysis of reactive astrocytes was performed by using GFAP and S-100 protein as specific markers. The study showed a significant increase in their number, size, number of processes, and density of immunostaining in 2,4-D-exposed animals. Exposure to 2,4-dichlorophenoxyacetic acid on the first days of life modifies the astroglial cytoarchitecture in parallel to previously described neuronal changes.

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Citations

Jan 27, 2004·Brain Research. Developmental Brain Research·Sergio Gustavo EvrardAlicia Brusco
Sep 16, 2003·Neurotoxicology and Teratology·Alejandro FerriAna María Evangelista de Duffard
Aug 10, 1999·Neurotoxicology and Teratology·A A BortolozziA M Evangelista de Duffard
Mar 17, 2007·Drug and Chemical Toxicology·Alejandro FerriAna María Evangelista de Duffard
Aug 13, 2011·Ecotoxicology and Environmental Safety·Afef TroudiNajiba Zeghal
Jan 3, 2014·Journal of Neurochemistry·Silvina TallisJuan C Perazzo
Jun 19, 2004·Neurotoxicology and Teratology·Analía A BortolozziMarta C Antonelli
Oct 12, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N StürtzR Duffard
Apr 30, 2004·Oncogene·Haiyun Y ChengMichael W Lieberman
Jul 10, 2002·Annals of the New York Academy of Sciences·Analía BortolozziAna María Evangelista de Duffard
Jul 10, 2002·Annals of the New York Academy of Sciences·Patricia TagliaferroAlicia Brusco
Jul 10, 2002·Annals of the New York Academy of Sciences·Ricardo Duffard, Ana Mariá Evangelista de Duffard
Jul 10, 2002·Annals of the New York Academy of Sciences·Alberto Javier RamosAlicia Brusco
Jan 23, 1998·Molecular and Chemical Neuropathology·P TagliaferroA Brusco

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