24-h Intraocular pressure control with evening-dosed travoprost/timolol, compared with latanoprost/timolol, fixed combinations in exfoliative glaucoma

Eye
A G P KonstasW C Stewart

Abstract

To evaluate 24-h efficacy of travoprost/timolol fixed combination (TTFC) vslatanoprost/timolol fixed combination (LTFC) in exfoliative glaucoma (XFG). A prospective, single-masked, crossover, active-controlled, randomized 24-h comparison. After up to a 6-week medicine-free period, XFG patients were randomized to either TTFC or LTFC for 3 months, dosed each evening, and then changed to the opposite treatment for another 3 months. At the end of the washout, and both treatment periods, a 24-h intraocular pressure (IOP) curve was measured. In total, 40 patients completed the study. The TTFC group showed a lower mean absolute 24-h IOP (18.7±2.6 vs 19.6±2.6 mm Hg, P<0.001), maximum IOP (20.5±2.6 vs 21.5±2.6 mm Hg, P<0.001) and 24-h IOP range (3.4±1.3 vs 4.1±1.6 mm Hg, P=0.01). At individual time points, TTFC showed reduced IOPs compared with LTFC, after a Bonferroni correction, at 1000, 1800, and 2200 hours (P≤0.04). No statistical differences existed at hours: 0600, 1400, and 0200 (P≥0.05) and for the minimum IOP (P=0.09). This study suggests that evening-dosed TTFC may provide greater 24-h IOP reduction, primarily at the 1800 hours time point, compared with LTFC in XFG.

References

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Jan 14, 2004·Archives of Ophthalmology·Anastasios G P KonstasWilliam C Stewart
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Citations

Aug 30, 2014·International Ophthalmology Clinics·Mohammed Khalil, Robert Ritch
Mar 1, 2012·Expert Opinion on Pharmacotherapy·Anastasios G P KonstasTony Realini
Jun 29, 2013·Expert Opinion on Pharmacotherapy·Anastasios Gp KonstasMurat Irkec
Apr 29, 2016·Expert Opinion on Pharmacotherapy·Anastasios G P Konstas, Gabor Holló
Jul 15, 2015·European Journal of Ophthalmology·Evangelia S PanagiotouAnastasios G P Konstas
Jul 3, 2018·Journal of Glaucoma·Aleksandra Z Michalik, Paul L Kaufman

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