PMID: 15379420Sep 24, 2004Paper

24-hour ambulatory blood pressure profile in patients with congenital adrenal hyperplasia--a preliminary report

Journal of Pediatric Endocrinology & Metabolism : JPEM
K S H de SilvaG L Warne

Abstract

Blood pressure (BP) is maintained within normal limits by the interplay of various mechanisms including the action of cortisol and aldosterone. However, these hormones when exogenously administered are not under the regulatory feedback mechanisms that maintain BP homeostasis. Treatment of congenital adrenal hyperplasia (CAH) requires glucocorticoid replacement (with or without additional mineralocorticoid) at supra-physiological doses to normalize the pituitary adrenocortical axis. Long-term use of glucocorticoids at supra-physiological doses may result in high BP. To document any changes in BP in patients with CAH following long-term conventional glucocorticoid replacement therapy. 24-hour ambulatory BP (AmBP) monitoring was performed in 11 patients with CAH, all of whom were on glucocorticoid replacement at supra-physiological doses. In addition, a single random BP measurement was taken in each patient at enrolment. Mean systolic and diastolic pressure during awake and sleep periods, systolic and diastolic BP loads, and systolic and diastolic BP dips were calculated from the 24-hour AmBP profile of each patient, which was correlated with demographic and treatment details. AmBP readings were compared to Task Force references f...Continue Reading

References

Apr 24, 2001·Current Opinion in Pediatrics·J M Sorof, R J Portman
Oct 3, 2002·Journal of Hypertension·Elke WühlUNKNOWN German Working Group on Pediatric Hypertension

❮ Previous
Next ❯

Citations

Jan 10, 2012·Endocrine·Henrik Falhammar, Marja Thorén
Feb 12, 2010·International Journal of Pediatric Endocrinology·Todd D Nebesio, Erica A Eugster
Jun 14, 2015·American Journal of Hypertension·Walter BonfigUNKNOWN AQUAPE CAH Study Group
Jun 4, 2011·Pharmacology & Therapeutics·H L Claahsen-van der GrintenA R M M Hermus
Apr 23, 2016·Clinical Endocrinology·Nadia Maccabee-RyaboyKyriakie Sarafoglou
May 15, 2007·Current Opinion in Pediatrics·Karen L McNiece, Ronald J Portman
Nov 19, 2014·The Journal of Clinical Endocrinology and Metabolism·Alberto M MarraMariacarolina Salerno
Sep 28, 2006·The Journal of Clinical Endocrinology and Metabolism·Thomas M K VölklHelmuth G Dörr
Aug 9, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Christiaan F MooijHedi L Claahsen-van der Grinten
Jun 23, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Wolfgang HoepffnerEberhard Keller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.