PMID: 9431859Feb 12, 1998Paper

24-hour blood pressure control by once-daily administration of irbesartan assessed by ambulatory blood pressure monitoring. Irbesartan Multicenter Investigators' Group

Journal of Hypertension
R FogariR Reeves

Abstract

To compare 24 h ambulatory blood pressure and trough office blood pressure lowerings after 8 weeks of therapy with 75 mg irbesartan once a day, 150 mg irbesartan once a day , and 75 mg irbesartan twice a day versus placebo; and to assess safety and tolerability of irbesartan therapy. Multicenter, double-blind, randomized, placebo-controlled trial. Sixteen centers in Italy. Caucasian patients (n = 215) aged > or = 18 years with seated diastolic blood pressure 95-110 mmHg and ambulatory diastolic blood pressure (ADBP) > or = 85 mmHg. Mean 24 h ADBP after 8 weeks of irbesartan therapy. Mean changes (value before treatment minus value after treatment) in ADBP for placebo, 75 mg irbesartan once a day, 150 mg irbesartan once a day, and 75 mg irbesartan twice a day were -0.2, -5.4, -7.2, and -7.2 mmHg, respectively; respective changes in ambulatory systolic blood pressure were +1.6, -8.3, -10.5, and -9.7 mmHg. All irbesartan regimens reduced trough office seated diastolic blood pressure and seated systolic blood pressure after 2 and 8 weeks of treatment (all P < 0.01, versus placebo except for seated systolic blood pressure in patients in the 75 mg irbesartan once a day group). Trough: peak ratios were > or = 55% with 150 mg irbesarta...Continue Reading

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Citations

Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuhei KawanoKaoru Yoshinaga
Dec 18, 2014·The Annals of Pharmacotherapy·Paul M StrangesAmie D Brooks
Feb 15, 2001·Circulation·M Burnier
Mar 24, 2006·Journal of Endocrinological Investigation·S ZacharievaE Nachev
Apr 13, 2001·Journal of Cardiovascular Pharmacology·J RibsteinA Mimran
Mar 20, 2004·Expert Review of Cardiovascular Therapy·Bernard Waeber, Michel Burnier
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Balraj S HeranJames M Wright
Feb 24, 2015·Expert Review of Pharmacoeconomics & Outcomes Research·Claudio BorghiArrigo F G Cicero
Jun 8, 2012·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Claudio Borghi, Arrigo F G Cicero
Dec 19, 2002·Blood Pressure Monitoring·Thomas G PickeringAmy R Schwartz
Jun 21, 2001·The Journal of Clinical Hypertension·D A Sica
Jan 27, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Stefano TaddeiLorenzo Ghiadoni
Aug 9, 2003·Expert Opinion on Drug Safety·Neil Shusterman
Jul 5, 2005·Expert Opinion on Investigational Drugs·C I Johnston

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