24-hour intraocular pressure control obtained with evening- versus morning-dosed travoprost in primary open-angle glaucoma

Ophthalmology
A G P KonstasW C Stewart

Abstract

To evaluate the quality of 24-hour intraocular pressure (IOP) control between morning- and evening-dosed travoprost in primary open-angle glaucoma patients. Prospective, crossover, double-masked comparison. After a 6-week medicine-free period, 33 patients were randomized to receive travoprost dosed in the morning or evening. After 8 weeks of treatment, a 24-hour IOP curve was performed at 6 am, 10 am, 2 pm, 6 pm, 10 pm, and 2 am. Patients were then treated with the opposite dosing regimen for another 8 weeks, after which the 24-hour IOP curve was repeated. Twenty-four-hour IOP. The untreated mean 24-hour IOP was 23.6+/-2.0 mmHg. There were no differences for mean 24-hour IOP between the morning (17.5+/-1.9 mmHg) and evening (17.3+/-1.9 mmHg) dosings (P = 0.7). At 10 am, the evening dosing provided a statistically lower IOP (17.2+/-2.1 mmHg) than the morning dosing (19.1+/-2.5 mmHg) (P = 0.02). Evening dosing demonstrated a statistically lower 24-hour fluctuation of IOP (3.2+/-1.0 mmHg) than morning dosing (4.0+/-1.5 mmHg) (P = 0.01). Safety was similar, with conjunctival hyperemia being the most common adverse event (n = 9 [27% for morning dosing] and n = 11 [33% for evening dosing], P = 0.6). This study suggests that both morn...Continue Reading

References

Feb 1, 1990·Clinical Biochemistry·M J Stewart
Aug 15, 1993·American Journal of Ophthalmology·W C StewartG Sethuraman
Feb 1, 1997·Archives of Ophthalmology·A G KonstasW C Stewart
May 8, 1998·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T K MundorfW C Stewart
Jun 1, 2001·American Journal of Ophthalmology·W C StewartM A Johnson
Oct 9, 2001·American Journal of Ophthalmology·P A NetlandUNKNOWN Travoprost Study Group
May 31, 2002·American Journal of Ophthalmology·Anastasios G P KonstasWilliam C Stewart
Jan 14, 2004·Archives of Ophthalmology·Leon W HerndonSandra S Stinnett
Jan 14, 2004·Archives of Ophthalmology·Anastasios G P KonstasWilliam C Stewart
Feb 5, 2005·Ophthalmology·Anastasios G P KonstasWilliam C Stewart

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Citations

Jul 17, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Elizabeth D SharpeWilliam C Stewart
Mar 26, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·William C StewartJeanette A Stewart
Mar 1, 2011·Expert Review of Pharmacoeconomics & Outcomes Research·Anton Hommer
Mar 1, 2011·Expert Opinion on Emerging Drugs·Anne J Lee, Ivan Goldberg
Sep 14, 2006·Current Medical Research and Opinion·J García-FeijooJ García-Sánchez
Oct 9, 2007·Clinical Therapeutics·Jean-Philippe Nordmann, Gilles Berdeaux
Feb 26, 2016·Advances in Therapy·Anastasios G P KonstasStefano Miglior
Mar 17, 2015·Journal of Glaucoma·Gábor HollóPéter Vargha
Nov 7, 2019·Journal of Glaucoma·Lauren CiullaAlon Harris
Mar 18, 2020·Investigative Ophthalmology & Visual Science·Keisuke IkegamiSatoru Masubuchi
Mar 6, 2008·European Journal of Ophthalmology·W C StewartB Kruft
Oct 24, 2019·Journal of Ophthalmology·Chun Hing Ho, Jasper K W Wong
Sep 1, 2018·Vestnik oftalmologii·S Yu PetrovA V Volzhanin
Oct 20, 2019·Survey of Ophthalmology·Kaweh MansouriRobert N Weinreb

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