24-hour rhythmicity of seizures in refractory focal epilepsy

Epilepsy & Behavior : E&B
Hipólito NzwaloCarla Bentes

Abstract

The occurrence of seizures in specific types of epilepsies can follow a 24-hour nonuniform or nonrandom pattern. We described the 24-hour pattern of clinical seizures in patients with focal refractory epilepsy who underwent video-electroencephalography monitoring. Only patients who were candidates for epilepsy surgery with an unequivocal seizure focus were included in the study. A total of 544 seizures from 123 consecutive patients were analyzed. Specific time of seizures were distributed along 3- or 4-hour time blocks or bins throughout the 24-hour period. The mean age of the subjects was 37.7years, with standard deviation of 11.5years, median of 37. The majority were females (70/56%). The majority of patients had a seizure focus located in the mesial temporal lobe (102/83%) and in the neocortical temporal lobe (13/11%). The remaining patients had a seizure focus located in the extratemporal lobe (8/6%). The most common etiology was mesial temporal sclerosis (86/69.9%). Nonuniform seizure distribution was observed in seizures arising from the temporal lobe (mesial temporal lobe and neocortical temporal lobe), with two peaks found in both 3- and 4-hour bins: 10:00-13:00/16:00-19:00 and 08:00-12:00/16:00-20:00 respectively (p=0....Continue Reading

References

Jul 1, 1984·Electroencephalography and Clinical Neurophysiology·A Martins da SilvaN Nagelkerke
Jan 31, 2004·Epilepsy & Behavior : E&B·Milena K PavlovaEdward B Bromfield
Apr 29, 2009·Sleep Medicine Reviews·Wytske Aelig Hofstra, Al Wytze de Weerd
Dec 3, 2009·Expert Review of Neurotherapeutics·Tiziana GranataDamir Janigro
Jun 29, 2010·Seizure : the Journal of the British Epilepsy Association·Matthew KarafinMark A Granner
Jan 12, 2011·Neurology·T LoddenkemperS V Kothare
Mar 15, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Tobias LoddenkemperSanjeev V Kothare

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Citations

May 16, 2020·Frontiers in Neurology·Magdalena K Smyk, Gilles van Luijtelaar
Jul 28, 2020·Frontiers in Neurology·Christopher J ReThomas N Ferraro
Jan 10, 2021·Epilepsy & Behavior : E&B·Shuyu WangUdaya Seneviratne
Feb 10, 2021·Epilepsy & Behavior : E&B·Madeleine Grigg-Damberger, Nancy Foldvary-Schaefer
Jan 11, 2019·Neuroscience and Biobehavioral Reviews·Daniel Leite Góes GitaiAshok K Shetty
Oct 28, 2018·Lancet Neurology·Sofia KhanSofia H Eriksson

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