PMID: 640235Mar 1, 1978Paper

24-hour studies of the effects of somatostatin on the levels of plasma growth hormone, glucagon, and glucose in normal subjects and juvenile diabetics

Diabetes
S E ChristensenK Lundbaek

Abstract

Somatostatin was infused in various doses into normal subjects and juvenile diabetics for a 24-hour period preceded by a 24-hour control period and followed by another three-hour control period. Saline was infused during the first control period. Meals were served during the two 24-hour periods. Blood samples were taken hourly. Five normal males received a total dose of 4 mg. somatostatin. Four male diabetics received 2 mg., four received 4 mg., and four 6 mg. In the diabetics, somatostatin suppressed plasma growth hormone, glucagon, and glucose throughout the infusion. All parameters rebounded at cessation of infusion. In the normals, somatostatin suppressed plasma growth hormone, glucagon, and insulin but increased plasma glucose. It is concluded that the plasma glucose suppression in the diabetics is mainly due to the suppression of the diabetogenic hormones growth hormone and glucagon. A minor effect of decreased and/or delayed absorption of carbohydrates cannot be excluded in these experiments. The elevated plasma glucose levels in normals must be due to the suppressive effects of somatostatin on insulin secretion.

Citations

Dec 14, 1978·The New England Journal of Medicine
Dec 1, 1992·European Journal of Clinical Investigation·J M KuhnL M Wolf
Jun 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·A Flyvbjerg
Feb 1, 1996·The Journal of Clinical Investigation·M RodenG I Shulman
Jun 1, 1979·Diabetologia·P J Lefebvre, A S Luyckx
Sep 1, 1991·Dental Economics - Oral Hygiene·D P Todzia
Mar 1, 1981·The American Journal of Medicine·J E Gerich
Aug 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·G Williams, S R Bloom
Jan 1, 1983·Transactions of the New York Academy of Sciences·B PetrackJ P Cassidy
Mar 13, 2014·SpringerPlus·Osman Nuri Dilek
Nov 29, 2016·Critical Reviews in Food Science and Nutrition·Giovanna MuscogiuriAnnamaria Colao
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·J E Gerich
Feb 1, 1988·Drug Intelligence & Clinical Pharmacy·M D KatzC Rose

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