PMID: 3758550Aug 1, 1986Paper

2,4-Pentanedione: 9-day and 14-week vapor inhalation studies in Fischer-344 rats

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
D E DoddB Ballantyne

Abstract

Fischer-344 rats, in groups of 10 males and 10 females, were exposed for 9 days (6 hr/day) to 2,4-pentanedione (2,4-PD) vapor at mean concentrations of 805, 418, 197, and 0 (control) ppm. No deaths occurred, and the only adverse signs were of sensory irritation (partial closure of eyelids, periocular and perioral wetness) at 805 ppm. Also at 805 ppm were decreased body and organ weights, lymphocytosis, and moderate inflammation of the nasal mucosa. At 418 ppm there was a decrease in body weight gain and mild inflammation of the nasal mucosa. Apart from minimal nasal mucosal inflammation, there were no effects at 197 ppm. In the subchronic (14-week) study, rats were exposed (6 hr/day; 5 days/week) to 650, 307, 101, and 0 (control) ppm of 2,4-PD vapor, using groups containing 20 males and 20 females, with half being sacrificed at the end of the exposure period and the remainder kept for a 4-week postexposure recovery period. An additional 10 males were added to the 650 and 0 ppm groups for glutaraldehyde perfusion and subsequent electron microscopic examination of sciatic nerves. At 650 ppm, all females and 10 of 30 males died between the second and sixth weeks of exposure. These animals had acute degenerative changes in the deep...Continue Reading

Citations

Aug 17, 2012·The American Journal of Pathology·Ann F HubbsKrishnan Sriram
Mar 12, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P CarthewS Gutsell
May 7, 1998·Toxicology and Industrial Health·S W FrantzH W Leung
May 1, 1989·Toxicology and Industrial Health·R W TylD E Dodd
Apr 5, 2001·Journal of Applied Toxicology : JAT·B Ballantyne, T J Cawley

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