24-Week Exposure to Oxidized Tyrosine Induces Hepatic Fibrosis Involving Activation of the MAPK/TGF-β1 Signaling Pathway in Sprague-Dawley Rats Model

Oxidative Medicine and Cellular Longevity
Zhuqing Leslie LiQi Zhao

Abstract

Oxidized tyrosine (O-Tyr) has been widely detected in many consumer protein products. O-Tyr products such as dityrosine (Dityr) and 3-nitrotyrosine (3-NT) are universal biomarkers of protein oxidation and have been demonstrated to be associated with metabolic disorders in biological system. Evaluation of potential intracorporal effects of dietary O-Tyr is important since the mechanism of biological impacts induced by oral oxidized protein products (OPPs) is still limited although we have proved that some dietary OPPs would induce oxidative injury to liver and kidney. The present study aimed to investigate the dose-dependent hepatic injury caused by oral O-Tyr in rats. 24-week feeding of O-Tyr enhanced aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, increased total bilirubin (TBiL) content, and led to oxidative damage in rats liver. Besides, O-Tyr distinctly increased the phosphorylation of p38 and ERK2 MAPKs and enhanced fibrosis-related TGF-β1 and Smad2/3 levels. Higher extracellular matrix (ECM) indexes (ICTP, PIIINP) and histological examination (HE and Masson staining) also supported dose-dependent hepatic fibrosis caused by O-Tyr. These findings reveal that O-Tyr may induce oxidative damage ...Continue Reading

References

Jul 1, 1993·British Medical Bulletin·K H Cheeseman, T F Slater
May 30, 1998·Journal of Gastroenterology·D M Bissell
Mar 3, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T WadaH Yokoyama
Dec 9, 2003·Amino Acids·D A Malencik, S R Anderson
Apr 4, 2007·Digestive Diseases and Sciences·Ali RezaieMohammad Abdollahi
Jun 10, 2008·Journal of Agricultural and Food Chemistry·Jasmin MeltretterMonika Pischetsrieder
Nov 12, 2009·Regulatory Toxicology and Pharmacology : RTP·Josef S OzerShashi K Ramaiah
Dec 17, 2009·American Journal of Physiology. Renal Physiology·Hyun Ju Kim, Nosratola D Vaziri
Jul 31, 2012·Journal of Agricultural and Food Chemistry·Mariana Utrera, Mario Estévez
Jun 26, 2013·Asian Pacific Journal of Tropical Medicine·Xiao-Lu Liang, Jia-Ying Yuan
Nov 10, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zhuqing Leslie LiYonghui Shi
Nov 26, 2013·The Medical Clinics of North America·Tinsay A Woreta, Saleh A Alqahtani
Jan 7, 2014·Alimentary Pharmacology & Therapeutics·A J Czaja

❮ Previous
Next ❯

Citations

Mar 1, 2017·Comprehensive Reviews in Food Science and Food Safety·Thomas Van HeckeStefaan De Smet
Jul 26, 2017·Journal of Agricultural and Food Chemistry·Yuhui YangGuowei Le
Jul 30, 2019·Journal of Agricultural and Food Chemistry·Bowen LiGuowei Le
Aug 14, 2020·Journal of Agricultural and Food Chemistry·Yipin LuHaoyi Ren

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
Polymerase Chain Reaction
reverse transcription PCR
MDA

Software Mentioned

MPI
Primer3
SPSS

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Sankhadeep PalParames C Sil
Nihon rinsho. Japanese journal of clinical medicine
Masato Abei
Nihon rinsho. Japanese journal of clinical medicine
Y Miura
Nihon rinsho. Japanese journal of clinical medicine
Y Miura
© 2022 Meta ULC. All rights reserved