2,4,6-Tribromophenol Exposure Decreases P-glycoprotein Transport at the Blood-Brain Barrier

Toxicological Sciences : an Official Journal of the Society of Toxicology
Andrew W TrexlerRonald E Cannon

Abstract

2,4,6-Tribromophenol (TBP, CAS No. 118-79-6) is a brominated chemical used in the production of flame-retardant epoxy resins and as a wood preservative. In marine environments, TBP is incorporated into shellfish and consumed by predatory fish. Food processing and water treatment facilities produce TBP as a byproduct. TBP has been detected in human blood and breast milk. Biologically, TBP interferes with estrogen and thyroid hormone signaling, which regulate important transporters of the blood-brain barrier (BBB). The BBB is a selectively permeable barrier characterized by brain microvessels which are composed of endothelial cells mortared by tight-junction proteins. ABC efflux transporters on the luminal membrane facilitate the removal of unwanted endobiotics and xenobiotics from the brain. In this study, we examined the in vivo and ex vivo effects of TBP on two important transporters of the BBB: P-glycoprotein (P-gp, ABCB1), and Multidrug Resistance-associated Protein 2 (MRP2, ABCC2), using male and female rats and mice. TBP exposure ex vivo resulted in a time- (1-3 h) and dose- (1-100 nM) dependent decrease in P-gp transport activity. MRP2 transport activity was unchanged under identical conditions. Immunofluorescence and wes...Continue Reading

References

Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LubahnO Smithies
Jan 1, 1996·Stem Cells·R L FineC W Sachs
May 9, 2002·Drug Metabolism Reviews·Richard B Kim
Jul 10, 2003·Environment International·Juliette Legler, Abraham Brouwer
Feb 21, 2004·Filaria Journal·Geoffrey Edwards
Sep 30, 2004·ILAR Journal·Vickie R Walker, Kenneth S Korach
Sep 2, 2005·International Journal of Environmental Health Research·Manuel GutiérrezRicardo Barra
Nov 16, 2007·Pharmaceutical Research·Naoki NishioKen-ichi Inui
Mar 4, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert R RigorDavid S Miller
Apr 27, 2010·Trends in Pharmacological Sciences·David S Miller
Mar 6, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sheila R ErnestBarbara F Hales
Mar 29, 2012·Advances in Experimental Medicine and Biology·Lily ZengPhilip M Newton
Dec 25, 2012·Biochimica Et Biophysica Acta·Douglas J SwartzIna L Urbatsch
Aug 21, 2013·Environmental Health Perspectives·Rajendrakumar A GosaviLars C Pedersen
Feb 24, 2016·Tropical Animal Health and Production·Olurotimi Ayobami Olafadehan, Oluwatosin Folashade Adebayo
Jul 16, 2016·International Journal of Environmental Research and Public Health·Dongoh LeeEui-Bae Jeung
Nov 26, 2016·Environmental Health : a Global Access Science Source·Christopher LeonettiHeather M Stapleton
Sep 9, 2017·Toxicology and Applied Pharmacology·Alexander ZarembaGert Fricker
Feb 11, 2018·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yvanna Carla de Souza SalgadoCiro Alberto de Oliveira Ribeiro
Oct 23, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Margaret E TomeThomas P Davis

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Citations

Dec 13, 2019·Toxicologic Pathology·June K DunnickArun Kumar R Pandiri
Aug 12, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gabriel A KnudsenLinda S Birnbaum
Sep 25, 2021·Environmental Science and Pollution Research International·Zhihua ZhaoYang Yang

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