Abstract
Calcium influx via L-type calcium channels in osteoblast cells causes a rapid (in seconds) elevation in intracellular calcium initiated by plasma membrane receptors for 1alpha, 25-dihydroxyvitamin D3 (1alpha,25-D3). 24R,25-Dihydroxyvitamin D3 (24,25-D3) alone, in concentrations up to 200 nM, does not cause potentiation of calcium currents in osteoblasts, but it does inhibit the current potentiation by 1alpha,25-D3. To determine how various steroids interact in their potentiation of calcium channels, the action of vitamin D3 analogues and testosterone with calcium channels in the rat osteoblast-like cell line ROS 17/2.8 was investigated. Bath additions of both 1alpha,25-D3 and testosterone at doses below K1/2 (the dose causing 50% left shift in the current-voltage relationship) are additive in their ability to potentiate calcium channels. When 1alpha,25-D3 and testosterone are added together at concentrations that would cause a maximal shift in the current-voltage relationship by each agent alone (Vmax), the effect of these steroids is not additive. Taken together these data suggest one population of calcium channels is activated by 1alpha, 25-D3 or testosterone. The shift in the current-voltage relationship caused by 1alpha,25-...Continue Reading
References
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·A W NormanM C Farach-Carson
Apr 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L X ZhouA W Norman
Dec 30, 1992·Biochemical and Biophysical Research Communications·A W NormanW H Okamura
Oct 1, 1991·Endocrinology·M C Farach-CarsonA W Norman
Jan 1, 1990·Annual Review of Physiology·G SchultzW Trautwein
Apr 11, 1991·Nature·S J TaylorJ H Exton
Feb 15, 1991·Science·A V SmrckaP C Sternweis
Jan 1, 1990·Annual Review of Physiology·W Trautwein, J Hescheler
Oct 1, 1990·Calcified Tissue International·G G LangstonB D Boyan
Aug 1, 1985·Nature·M C NowyckyR W Tsien
Jan 2, 1987·Science·R J Miller
Mar 19, 1987·Nature·M Kuno, P Gardner
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S E GugginoS H Snyder
Jan 1, 1989·Annual Review of Physiology·B P Bean
Jul 7, 1989·Science·A Yatani, A M Brown
Dec 1, 1986·Journal of Steroid Biochemistry·Y Yoshimoto, A W Norman
Jul 23, 1987·Nature·T TanabeS Numa
Jul 1, 1988·Science·B S KommM R Haussler
Jul 1, 1988·Science·E F EriksenB L Riggs
Apr 1, 1988·The Journal of Physiology·D Chesnoy-Marchais, J Fritsch
Jun 1, 1986·Endocrinology·Y YoshimotoA W Norman
Jun 15, 1983·The Biochemical Journal·M J Berridge
Oct 1, 1984·Endocrinology·I NemereA W Norman
Nov 3, 1983·Nature·H StrebI Schulz
Sep 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B GrosseM Lieberherr
Jul 15, 1993·Nature·A SculptoreanuW A Catterall
Mar 1, 1996·Cell Calcium·B LiE Karpinski
Citations
Aug 12, 1998·Journal of Cellular Physiology·B D BoyanZ Schwartz
Aug 10, 1999·Developmental Genetics·F EspinosaA Darszon
Sep 5, 2002·Journal of Cellular Biochemistry·Carolina BaldiRicardo Boland
Sep 27, 2001·Journal of Cellular Biochemistry·D LarssonK Sundell
Feb 22, 2002·Steroids·Barbara D BoyanZvi Schwartz
Apr 19, 2002·Steroids·Barbara D BoyanZvi Schwartz
Jun 22, 1999·Molecular and Cellular Endocrinology·C E BergerH K Datta
Apr 12, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Myrtle Thierry-PalmerKeri Griffin
Sep 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A W Norman
Sep 1, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·I Nemere
Jul 14, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·X T WangS E Guggino
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GlendenningR L Prince
Oct 9, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jiliang LiCharles H Turner
Jun 13, 2001·Biochemical and Biophysical Research Communications·Y GuS J Publicover
Jan 30, 2015·Scientific Reports·Zhongyang SunManjiang Xie
Sep 5, 1997·The Journal of Biological Chemistry·L P Zanello, A W Norman
Mar 8, 2006·Journal of Neuroscience Research·Hideo TaniuraYukio Yoneda
Dec 3, 2010·Hippocampus·Ying ZhuLing Chen
Jan 18, 2007·Journal of Cellular Biochemistry·Sven L Peery, Ilka Nemere
Mar 23, 2006·Journal of Cellular Biochemistry·Dennis LarssonIlka Nemere
Oct 14, 2005·American Journal of Physiology. Cell Physiology·Joel J BerghMary C Farach-Carson
Jun 29, 2002·Molecular Endocrinology·Reinhold G ErbenRudi Balling
Dec 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joyce C McCann, Bruce N Ames
Mar 21, 2008·American Journal of Physiology. Cell Physiology·Annamaria MorelliMario Maggi
Jul 29, 2006·Endocrinology·Guido MichelsUta C Hoppe
Aug 19, 2000·American Journal of Physiology. Endocrinology and Metabolism·I NemereK Sundell
Aug 15, 1998·Biochemical and Biophysical Research Communications·I Nemere, M C Farach-Carson
Jul 14, 2004·Molecular and Cellular Endocrinology·Denis CouchourelMichèle G Brunette
Jun 20, 2006·Cell Calcium·Lawrence D BrewerOlivier Thibault