PMID: 9178190May 1, 1997Paper

2',5'-Dihydroxychalcone as a potent chemical mediator and cyclooxygenase inhibitor

The Journal of Pharmacy and Pharmacology
C N LinC M Teng

Abstract

Eleven chalcone derivatives have been tested for their inhibitory effects on platelet aggregation in rabbit platelet suspension and the activation of mast cells and neutrophils. Arachidonic acid-induced platelet aggregation was potently inhibited by almost all the compounds and some also had a potent inhibitory effect on collagen-induced platelet aggregation and cyclooxygenase. Some hydroxychalcone derivatives showed strong inhibitory effects on the release of beta-glucuronidase and lysozyme, and on superoxide formation by rat neutrophils stimulated with the peptide fMet-Leu-Phe (fMLP). We found that the anti-inflammatory effect of 2',5'-dihydroxychalcone was greater than that of trifluoperazine. 2'5'-Dihydroxy and 2',3,4,5'-tetrahydroxyl chalcones, even at low concentration (50 microM), tested in platelet-rich plasma from man almost completely inhibited secondary aggregation induced by adrenaline. These results suggest that the anti-platelet effects of the chalcones are mainly a result of inhibition of thromboxane formation.

References

Mar 23, 1978·The New England Journal of Medicine·B M Babior
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Jan 1, 1964·British Journal of Haematology·J R MITCHELL, A A SHARP

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Citations

Mar 14, 2000·The Journal of Pharmacy and Pharmacology·H K HsiehC N Lin
Oct 16, 2004·The Journal of Pharmacy and Pharmacology·Horng-Huey KoChun-Nan Lin
Sep 24, 2019·Experimental Mechanics·M M Islam, R L Steward
Sep 3, 2009·Annals of the New York Academy of Sciences·M R HeidariA Eskandarizadeh
Feb 19, 2008·European Journal of Medicinal Chemistry·K L LahtchevA A Sibirny

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