25-Hydroxvitamin D concentrations are not lower in children with bronchial asthma, atopic dermatitis, obesity, or attention-deficient/hyperactivity disorder than in healthy children

Nutrition Research
Thomas ReinehrKarl-Heinz Jöckel

Abstract

Vitamin D (vitD) is involved in immune regulation, and its receptor has been identified in several tissues including lung, adipose tissue, brain, and skin. Based on these observations, it has been suggested that vitD has an essential role not only in bone metabolism but also in other diseases such as atopic dermatitis (AD), bronchial asthma (BA), attention-deficit/hyperactivity disorder (ADHD), and obesity because the affected tissues express vitD receptors. Furthermore, obesity, AD, and BA are regarded as inflammatory diseases. Therefore, we hypothesized that vitD concentrations are lower in children with AD, BA, ADHD, and obesity compared to healthy children. We measured 25-hydroxyvitamin D concentrations in 235 children (60% boys, age 9.3±1.7years) with obesity, BA, AD, or ADHD and compared them to those of 3352 children from a healthy population. Additionally, parathyroid hormone was measured in the children with obesity, ADHD, BA, and AD. VitD concentrations were not lower in children with obesity, ADHD, BA, and AD compared to healthy children. In multiple regression analyses adjusted to migration background, time period of blood sample, age, and sex, VitD levels correlated significantly with the severity of AD measured by...Continue Reading

Citations

Jan 5, 2019·Current Opinion in Allergy and Clinical Immunology·Augusto A Litonjua
Mar 27, 2019·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Alexandra R VaughnVivian Y Shi
Sep 13, 2020·International Journal of Environmental Research and Public Health·Teodora-Irina Adam-BonciAlexandru Irimie
Oct 9, 2019·Respiratory Research·Jian LiuWei-Fang Wu
Sep 16, 2020·Pediatric Pulmonology·Brian P O'SullivanUNKNOWN IDeA States Pediatric Clinical Trials Network
Jan 4, 2021·The Journal of Nutritional Biochemistry·Shaniya AhmadMansoor Ali Syed
Aug 10, 2021·Journal of Pediatric Nursing·Qiong WangJunguo Chen

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