25-Hydroxycholecalciferol Enhances Male Broiler Breast Meat Yield through the mTOR Pathway

The Journal of Nutrition
Karen VignaleCraig N Coon

Abstract

In recent years, there has been a growing body of evidence indicating that replacing cholecalciferol (vitamin D₃) with 25-hydroxycholecalciferol [25(OH)D₃] through dietary supplementation enhances breast meat yield in broiler chickens. However, the underlying molecular mechanisms are still unknown. We investigated the effect of 25(OH)D₃ on male broiler growth performance (body weight, feed intake, feed conversion ratio, and breast meat yield), muscle protein synthesis, and the potential underlying molecular mechanisms. Male Cobb 500 broiler chickens were divided into 4 body weight-matched groups and received a control diet with normal cholecalciferol (2760 IU/kg feed) for 42 d, a diet with high concentrations of cholecalciferol (5520 IU/kg feed) for 42 d, or a diet with 25(OH)D₃ (5520 IU/kg feed) for 42 d (HyD-42). A fourth group consumed the HyD-42 for 21 d and then control feed for 21 d (HyD-21) (n = 360 birds, 12 replicates/treatment). Food and clean water were available for ad libitum consumption. At the end of the 42-d experiment, protein turnover was measured by phenylalanine flooding dose. Breast muscle tissues were collected and protein synthesis-related gene and protein expression were measured by real time polymerase ...Continue Reading

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Citations

Jan 27, 2018·Journal of Animal Science and Biotechnology·Ahmed Mohamed FouadChuntian Zheng
Oct 29, 2015·American Journal of Physiology. Endocrinology and Metabolism·Daniel J OwensGraeme L Close
Sep 15, 2018·Journal of Animal Science and Biotechnology·Marco ZampigaFederico Sirri
May 13, 2021·Current Developments in Nutrition·Matthew F Warren, Kimberly A Livingston
Sep 10, 2021·Genetics, Selection, Evolution : GSE·Christos DadousisJohn M Hickey

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