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25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

bioRxiv

Jan 15, 2020

Man Ying WongWenjie Luo

Abstract

Genome-wide association studies associated with Alzheimer′s disease (AD) have implicated pathways related to both lipid homeostasis and innate immunity in the pathophysiology of AD. However, the exact cellular and chemical mediators of neuroinflammation in AD remain poorly understood. T...read more

Mentioned in this Paper

Molecular_function
Laboratory mice
Interleukin-1 beta
Inflammation
Pathology
Immunomodulators
Brain Tissue
APOE gene
Caspase-1
Tau Proteins
4
Paper Details
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Proceedings of the National Academy of Sciences of the United States of America

25-Hydroxycholesterol acts as an amplifier of inflammatory signaling

Proceedings of the National Academy of Sciences of the United States of AmericaJuly 6, 2014
Elizabeth S GoldAlan Aderem
© 2020 Meta ULC. All rights reserved

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

bioRxiv

Jan 15, 2020

Man Ying WongWenjie Luo

DOI: 10.1101/2020.01.14.906966

Abstract

Genome-wide association studies associated with Alzheimer′s disease (AD) have implicated pathways related to both lipid homeostasis and innate immunity in the pathophysiology of AD. However, the exact cellular and chemical mediators of neuroinflammation in AD remain poorly understood. T...read more

Mentioned in this Paper

Molecular_function
Laboratory mice
Interleukin-1 beta
Inflammation
Pathology
Immunomodulators
Brain Tissue
APOE gene
Caspase-1
Tau Proteins
4

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Tau Toxicity in the Synapses

Tau toxicity has been implicated in the emergence of synaptic dysfunction in Alzheimer's disease. Here is the latest research on Tau Toxicity in the Synapses.

Tau Aggregation: Genomics

Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

25-Hydroxycholesterol acts as an amplifier of inflammatory signaling

Proceedings of the National Academy of Sciences of the United States of AmericaJuly 6, 2014
Elizabeth S GoldAlan Aderem
Paper Details
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