25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966.

American Journal of Epidemiology
Dylan M WilliamsMarjo-Riitta Järvelin

Abstract

Higher vitamin D status, lower adiposity, and longer telomere length are each reportedly associated with lower risk of several chronic diseases and all-cause mortality. However, direct relationships between vitamin D status (measured by circulating 25-hydroxyvitamin D (25(OH)D) concentration), adiposity, and telomere length are not well established. We conducted a cross-sectional analysis of associations of 25(OH)D and body mass index (BMI; weight (kg)/height (m)(2)) with mean relative leukocyte telomere length (LTL) using data gathered on 5,096 participants from Northern Finland Birth Cohort 1966 at age 31 years (1997). 25(OH)D was not associated with LTL in either basic or confounder/mediator-adjusted models. BMI was inversely associated with LTL after adjustment for potential confounding by age, sex, socioeconomic position, physical activity, diet, smoking, alcohol intake, and use of oral contraceptives (per 1-unit increase in BMI, mean difference in LTL = -0.4%, 95% confidence interval: -0.6, -0.2). The BMI-LTL association was also independent of 25(OH)D and was attenuated slightly, but remained, after adjustment for C-reactive protein, a marker of low-grade inflammation (mean difference in LTL = -0.3%, 95% confidence inter...Continue Reading

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Citations

Aug 16, 2016·The British Journal of Nutrition·Jason J LiuD Michal Freedman
Nov 23, 2019·Nutrients·Johanna LummeMaarit Niinimäki
Apr 24, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Valentin Max VetterIlja Demuth
May 2, 2017·Climacteric : the Journal of the International Menopause Society·M N Gunning, B C J M Fauser
Mar 5, 2021·The World Journal of Men's Health·Patrizia D'Amelio

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