25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men.

Neurology
Yelena SlininOsteoporotic Fractures in Men (MrOS) Study Research Group

Abstract

To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline. We measured 25(OH)D and assessed cognitive function using the Modified Mini-Mental State Examination (3MS) and Trail Making Test Part B (Trails B) in a cohort of 1,604 men enrolled in the Osteoporotic Fractures in Men Study and followed them for an average of 4.6 years for changes in cognitive function. In a model adjusted for age, season, and site, men with lower 25(OH)D levels seemed to have a higher odds of cognitive impairment, but the test for trend did not reach significance (impairment by 3MS: odds ratio [OR] 1.84, 95% confidence interval [CI] 0.81-4.19 for quartile [Q] 1; 1.41, 0.61-3.28 for Q2; and 1.18, 0.50-2.81 for Q3, compared with Q4 [referent group; p trend = 0.12]; and impairment by Trails B: OR 1.66, 95% CI 0.98-2.82 for Q1; 0.96, 0.54-1.69 for Q2; and 1.30, 0.76-2.22 for Q3, compared with Q4 [p trend = 0.12]). Adjustment for age and education further attenuated the relationships. There was a trend for an independent association between lower 25(OH)D levels and odds of cognitive decline by 3MS performance (multivariable OR 1.41, 95% CI 0.89-2.23 f...Continue Reading

Citations

Mar 29, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yelena SlininUNKNOWN Study of Osteoporotic Fractures Research Group
Apr 12, 2012·Journal of Epidemiology and Community Health·Anna-Maija TolppanenDebbie A Lawlor
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Counci
Oct 13, 2010·Journal of Neuroengineering and Rehabilitation·Cedric AnnweilerOlivier Beauchet
Sep 26, 2012·Neurology·Cynthia BalionParminder Raina
Jul 19, 2012·PloS One·Anna-Maija TolppanenDebbie A Lawlor
Jun 19, 2013·PloS One·Yuri MilaneschiUNKNOWN Health ABC study
May 23, 2013·Clinical Interventions in Aging·Bárbara Rita CardosoSilvia Maria Franciscato Cozzolino
Oct 12, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Manjula Kurella TamuraAlan S Go
Sep 21, 2013·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Junko OkunoHisako Yanagi
Apr 15, 2014·Clinical Interventions in Aging·Mathias Schlögl, Michael F Holick
Jun 21, 2014·Biologie aujourd'hui·Pascal MilletFrançois Féron
Mar 29, 2014·The Journal of Nutrition, Health & Aging·B BartaliJ H Kang
Jul 19, 2013·BioMed Research International·Nan HuLan Tan
Jul 18, 2014·Annual Review of Nutrition·Natalie J GrovesThomas H J Burne
Dec 12, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E M Brouwer-BrolsmaL C P G M de Groot
Apr 14, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrea L MettiKristine Yaffe
Sep 13, 2014·Epidemiology·Paul KnektMarkku Heliövaara
Jun 26, 2012·European Journal of Nutrition·Elske M Brouwer-BrolsmaLisette C P G M de Groot
Jul 6, 2010·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Elizabeth Pogge
Aug 28, 2014·European Journal of Clinical Nutrition·P Barberger-Gateau
Aug 12, 2010·European Journal of Clinical Nutrition·K M SeamansK D Cashman
Dec 14, 2011·Neuroepidemiology·Cédric Annweiler, Olivier Beauchet
Oct 12, 2011·Drugs·David O Kennedy, Crystal F Haskell
Jul 5, 2012·Dementia and Geriatric Cognitive Disorders·Thorleif EtgenHans Förstl
Jul 28, 2011·CNS Drugs·Andy P DickensDavid J Llewellyn
Jun 15, 2012·Food & Function·Meinrad Peterlik
Apr 25, 2013·Current Atherosclerosis Reports·Muhammad U Farooq, Philip B Gorelick
Nov 26, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Hataikarn Nimitphong, Michael F Holick
Feb 3, 2016·Physiology & Behavior·Natalie J Groves, Thomas H J Burne
Mar 1, 2016·Neurobiology of Aging·Alexandra M KueiderMadhav Thambisetty
Aug 14, 2012·Journal of Critical Care·Alessandro MorandiL B Ware
Nov 30, 2011·Experimental Gerontology·Lutz P BreitlingHermann Brenner
Jan 30, 2010·Ageing Research Reviews·Thorleif EtgenHans Förstl
Dec 23, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Liisa BybergKarl Michaëlsson
Nov 28, 2012·Journal of the American Geriatrics Society·Rebecca C RossomKaren L Margolis
Mar 31, 2012·Pharmacotherapy·Stuart T Haines, Sharon K Park
Feb 7, 2013·British Journal of Clinical Pharmacology·Sophie Gillette-GuyonnetBruno Vellas
Aug 18, 2012·Hemodialysis International·Darius L MasonHassan A N El-Fawal
Mar 19, 2014·Journal of the American Geriatrics Society·Valerie K WilsonUNKNOWN Health, Aging and Body Composition Study
May 23, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A L C SchneiderE D Michos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.