25 years of African trypanosome research: From description to molecular dissection and new drug discovery

Molecular and Biochemical Parasitology
Keith R Matthews

Abstract

The Molecular Parasitology conference was first held at the Marine Biological laboratory, Woods Hole, USA 25 years ago. Since that first meeting, the conference has evolved and expanded but has remained the showcase for the latest research developments in molecular parasitology. In this perspective, I reflect on the scientific discoveries focussed on African trypanosomes (Trypanosoma brucei spp.) that have occurred since the inaugural MPM meeting and discuss the current and future status of research on these parasites.

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Citations

Jul 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Zhao-Rong LunFrancisco J Ayala
Nov 3, 2015·Seminars in Cell & Developmental Biology·Timothy Krüger, Markus Engstler
Mar 22, 2016·Molecular and Biochemical Parasitology·Carla Cristi D C AvilaBeatriz A Castilho
Aug 9, 2016·Molecular and Biochemical Parasitology·Michael R McAllasterChristopher L de Graffenried
Oct 14, 2016·Frontiers in Pharmacology·Jose A Garcia-SalcedoMiguel Soriano
Apr 23, 2016·PLoS Pathogens·Hassan HashimiJulius Lukeš
Apr 4, 2017·Parasitology International·Albertus Eka Yudistira SarwonoMakoto Ubukata
Feb 12, 2017·Bioorganic & Medicinal Chemistry·Eoin R GouldGordon J Florence
Mar 25, 2018·Scientific Reports·Michaela ProcházkováAlena Zíková
Apr 18, 2017·PLoS Neglected Tropical Diseases·Brian PanicucciAlena Zíková
Jun 24, 2017·Frontiers in Cellular and Infection Microbiology·Totta EhretFrank Seeber
Jun 19, 2019·The Journal of Eukaryotic Microbiology·Noelia Lander, Miguel A Chiurillo
Apr 25, 2019·Tropical Diseases, Travel Medicine and Vaccines·Leila MakhaniAndrea K Boggild
Dec 20, 2019·PLoS Pathogens·Hassan Hashimi
Mar 16, 2021·Open Biology·Alexei Y KostygovJulius Lukeš
Jul 25, 2020·Trends in Parasitology·Akila YagoubatYvon Sterkers
Jun 6, 2017·Biochemistry·Danielle L Schmitt, Songon An

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Methods Mentioned

BETA
PCR
in vitro transcription
gene knockout
transgenic
gene knock out
electrophoresis
immunoprecipitation
RNA-Seq
transfection
dissection

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African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.