25I-NBOMe related death in Australia: a case report

Forensic Science International : Synergy
Victoria B Kueppers, Clive T Cooke

Abstract

We present a toxicologically confirmed 25I-NBOMe related death from Australia. 25I-NBOMe is a synthetic new psychoactive substance (NPS), which is a derivative of the 2C-X series of phenethylamines. NBOMe compounds have hallucinogenic and stimulant properties and are potent agonists of the human 5HT2A receptor. They have been associated with severe toxicity and fatalities. No case reports on deaths related to 25I-NBOMe toxicity from Australia have been published thus far. Very limited toxicological data is available in the current literature. The decedent in the presented case had a post mortem aortic non-preserved blood concentration of 25I-NBOMe of approximately 28 μg/L, a concentration that appears to be much higher than those previously reported in non-fatal cases of toxicity and analytically confirmed 25I-NBOMe related fatalities. The publication of new data is essential in improving knowledge and awareness amongst the forensic community regarding emerging psychoactive substances, such as the NBOMe compounds.

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Citations

Dec 2, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Paul GeeStuart Barrington
Oct 21, 2015·Drug and Alcohol Dependence·Jolanta B Zawilska, Dariusz Andrzejczak
May 22, 2016·Journal of Analytical Toxicology·John J KristoficThomas Z Bosy
Jul 13, 2016·Drug Testing and Analysis·Line Marie NielsenKristian Linnet
Mar 7, 2017·Journal of Forensic Sciences·James W RajotteHelena Rachelle Wallage
May 5, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Maren Hermanns-ClausenVolker Auwärter
Aug 16, 2017·Drug Testing and Analysis·Rohan EdmundsDominic Reynolds
Dec 18, 2019·Drug Testing and Analysis·Elias LützenUwe Karst
Mar 5, 2020·Journal of Analytical Toxicology·Katarzyna KamińskaKamilla Malek
Sep 18, 2015·The Medical Journal of Australia·Geoffrey K IsbisterJeffrey Grice
Mar 17, 2020·Frontiers in Neuroscience·Jolanta B ZawilskaPiotr Adamowicz
Apr 7, 2020·Archives of Toxicology·Dino Luethi, Matthias E Liechti
Jan 10, 2020·Frontiers in Pharmacology·Cristina MilianoMaria Antonietta De Luca
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Oct 29, 2019·ACS Chemical Neuroscience·Christian B M PoulieJesper L Kristensen
Aug 31, 2021·Journal of the American Society for Mass Spectrometry·Henry WestGavin E Reid

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