2,6-DMBQ is a novel mTOR inhibitor that reduces gastric cancer growth in vitro and in vivo.

Journal of Experimental & Clinical Cancer Research : CR
Xueyin ZuDong Joon Kim

Abstract

Fermented wheat germ extract has been reported to exert various pharmacological activities, including anti-oxidant, anti-cell growth and cell apoptosis in various cancer cells. Although 2,6-dimethoxy-1,4-benzoquinone (2,6-DMBQ) is a benzoquinone compound and found in fermented wheat germ extract, its anticancer effects and molecular mechanism(s) against gastric cancer have not been investigated. Anticancer effects of 2,6-DMBQ were determined by MTT, soft agar, cell cycle and Annexin V analysis. Potential candidate proteins were screened via in vitro kinase assay and Western blotting. mTOR knockdown cell lines were established by lentiviral infection with shmTOR. The effect of 2,6-DMBQ on tumor growth was assessed using gastric cancer patient-derived xenograft models. 2,6-DMBQ significantly reduced cell growth and induced G1 phase cell cycle arrest and apoptosis in gastric cancer cells. 2,6-DMBQ reduced the activity of mTOR in vitro. The inhibition of cell growth by 2,6-DMBQ is dependent upon the expression of the mTOR protein. Remarkably, 2,6-DMBQ strongly reduced patient-derived xenograft gastric tumor growth in an in vivo mouse model. 2,6-DMBQ is an mTOR inhibitor that can be useful for treating gastric cancer. It has therape...Continue Reading

References

Aug 18, 2004·Genes & Development·Nissim Hay, Nahum Sonenberg
Aug 13, 2005·Advances in Cancer Research·Alfonso BellacosaJoseph Robert Testa
Feb 3, 2006·Cancer Research·Kathryn E O'ReillyNeal Rosen
Aug 8, 2007·Cell Research·Qian Yang, Kun-Liang Guan
Feb 12, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jing-Song ChenLong-Juan Zhang
Sep 10, 2009·International Journal of Cancer. Journal International Du Cancer·Ji Yeong AnSung Kim
Oct 12, 2010·The International Journal of Biochemistry & Cell Biology·Tim R Fenton, Ivan T Gout
Dec 16, 2010·Nature Reviews. Molecular Cell Biology·Roberto ZoncuDavid M Sabatini
Mar 31, 2011·Nature Reviews. Clinical Oncology·Lisa Hutchinson, Rebecca Kirk
Apr 19, 2011·Journal of Experimental & Clinical Cancer Research : CR·Thomas MuellerWieland Voigt
Sep 8, 2011·International Journal of Cancer. Journal International Du Cancer·Salah-Eddin Al-BatranAtsushi Ohtsu
Jun 5, 2013·Cancer Research·Despina Siolas, Gregory J Hannon
Aug 28, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zhi Rong QianMatthew H Kulke
Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi OhtsuEric Van Cutsem
Feb 22, 2014·Nature Reviews. Molecular Cell Biology·Mitsugu Shimobayashi, Michael N Hall
Sep 4, 2014·Cancer Discovery·Manuel HidalgoAlberto Villanueva
Sep 12, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun-ichi KawadaHiroshi Kimura
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Sep 25, 2015·Pharmacogenomics·Daniela SiaAugusto Villanueva
Dec 24, 2015·Journal of Gastrointestinal and Liver Diseases : JGLD·Simona ValeanAnca Trifan
May 9, 2016·Pathology Oncology Research : POR·Ismael RiquelmeJuan Carlos Roa
Nov 1, 2016·European Surgery : ACA : Acta Chirurgica Austriaca·G Jomrich, S F Schoppmann
Mar 9, 2017·Clinical and Experimental Pharmacology & Physiology·Batoul FarranRaquel C Montenegro
Apr 22, 2017·Cell·Brendan D Manning, Alex Toker
May 23, 2017·Cancer Cell·Yiqun ZhangChad J Creighton
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Sep 27, 2018·Medicinal Research Reviews·Mohammed S Abdel-MaksoudChang-Hyun Oh
Oct 15, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tomonori KamiyaSakae Arimoto-Kobayashi
Oct 31, 2018·International Journal of Cancer. Journal International Du Cancer·Kui ZhangZhenhua Deng
Jan 4, 2019·Nature Cell Biology·Joungmok Kim, Kun-Liang Guan
Aug 25, 2019·Cancer Treatment Reviews·Massimiliano SalatiStefano Cascinu

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Citations

May 13, 2021·Biochemical and Biophysical Research Communications·Yuning WangGuanghai Dai
Aug 1, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ahyoung YooTae Youl Ha

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Methods Mentioned

BETA
Assay
flow cytometry
xenograft
Fluorescence Activated Cell Sorting
xenografts

Software Mentioned

statistical package for social science
Pro PLUS
Image J ( NIH )
Image
Image J ( NIH

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