+294T/C polymorphism in the PPAR-delta gene is associated with risk of coronary artery disease in normolipidemic Tunisians

Genetics and Molecular Research : GMR
I Jguirim-SouissiM N Slimane

Abstract

Peroxisome proliferator-activated receptor delta (PPAR-delta) is a transcription factor implicated in metabolism and inflammation. The +294T/C polymorphism in the PPAR-delta gene is associated with risk of coronary artery disease (CAD) in dyslipidemic women and hypercholesterolemic men. Whether this polymorphism influences the risk of CAD in the absence of dyslipidemia was not known, so we investigated a possible association of this polymorphism with plasma lipid and lipoprotein levels and with risk and outcome of CAD in a normolipidemic Tunisian population. Genotyping was performed by PCR-RFLP in 112 CAD patients and 113 healthy volunteers. The C-allele was significantly more frequent in patients than in controls (0.320 vs 0.189, P = 0.001). This association remained significant after adjustment for age, gender, body mass index, smoking, hypertension, and high-density lipoprotein cholesterol. Subjects carrying either one or two copies of the C-allele had a 2.7-fold higher risk of CAD than subjects homozygous for the T-allele. PPAR-delta genotypes were not associated with lipoprotein concentrations or outcome of CAD. We conclude that PPAR-delta +294T/C polymorphism is an independent risk factor of CAD in normolipidemic Tunisian...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
May 20, 2000·FEBS Letters·M D LeibowitzJ Auwerx
Feb 25, 2003·Lancet·Lon R Cardon, Lyle J Palmer
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Josefin SkogsbergEwa Ehrenborg
Mar 19, 2003·Lancet·Helen M ColhounGeorge Davey Smith
May 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·John S WelchChristopher K Glass
Dec 4, 2004·The Journal of Clinical Investigation·Andrew C LiChristopher K Glass
Oct 22, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Florian BlaschkeWilla A Hsueh
Apr 29, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Jun-Yang LiouKenneth K Wu
Aug 15, 2006·International Journal of Medical Sciences·Jens AberleUdo Seedorf
Oct 28, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Laura PiquerasDavid Bishop-Bailey
Jun 26, 2007·Biochimica Et Biophysica Acta·Udo Seedorf, Jens Aberle
Mar 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Grant D BarishChih-Hao Lee

❮ Previous
Next ❯

Citations

Jul 28, 2016·International Journal of Molecular Sciences·Jian GuoXiao-Li Tian
Mar 15, 2012·Journal of Nutrigenetics and Nutrigenomics·Annie Bouchard-MercierMarie-Claude Vohl
Aug 30, 2018·PloS One·Agata Leońska-DuniecAgnieszka Maciejewska-Skrendo
Oct 16, 2013·Atherosclerosis·Ewa Ehrenborg, Josefin Skogsberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.