2B or not 2B: a tail of two NMDA receptor subunits.

Neuron
Carlos Cepeda, Michael S Levine

Abstract

N-methyl-D-aspartate (NMDA) receptor activation can be neuroprotective or neurotoxic depending on receptor location. In this issue of Neuron, Martel et al. (2012) demonstrate that the C-terminal of NMDA receptor subunits also contributes critically to excitotoxicity. NMDA receptor subunits containing the GluN2B C-terminal are more lethal than those containing the GluN2A tails, regardless of location.

Citations

Jan 25, 2020·Journal of Neurochemistry·Marta VieiraVictor Anggono

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