2D Ti2 C (MXene) as a novel highly efficient and selective agent for photothermal therapy

Materials Science & Engineering. C, Materials for Biological Applications
Aleksandra SzuplewskaAndrzej Olszyna

Abstract

Photothermal therapy (PTT) has shown significant potential for anti-cancer modality. In this report, according to our best knowledge, we explore for the first time Ti2C-based MXene as a novel, highly efficient and selective agent for photothermal therapy (PTT). Ti2C superficially modified with PEG was obtained from the layered, commercially available Ti2AlC MAX phase in the process of etching aluminum layers using concentrated HF, and characterized by scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HREM) as well as X-ray photoelectron spectroscopy for chemical analysis (ESCA-XPS). The PEG-coated Ti2C flakes showed a satisfactory photothermal conversion efficacy (PTCE) and good biocompatibility in wide range of the tested concentrations. Through in vitro studies, the PEG-modified Ti2C demonstrated notable NIR-induced ability to cancerous cells' ablation with minimal impact on non-malignant cells up to the concentration of 37.5 μg mL-1. The applied doses of Ti2C_PEG in our work were even 24 times lower comparing other MXene-based photothermal agents. This work is expected to expand the utility of 2D MXenes to biomedical applications through the development of entirely novel agents for phototh...Continue Reading

Citations

May 24, 2020·Materials·Anita Rozmysłowska-WojciechowskaAgnieszka M Jastrzębska
May 16, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Aravindkumar SundaramJoao Gaspar
Aug 23, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yan GaoChongshen Guo
Nov 13, 2019·Journal of Nanobiotechnology·A SzuplewskaA M Jastrzębska
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·A Rozmysłowska-WojciechowskaA M Jastrzębska
Apr 15, 2021·ACS Biomaterials Science & Engineering·Siavash Iravani, Rajender S Varma
Apr 21, 2021·Advanced Healthcare Materials·Moyuan QuAli Khademhosseini
Jun 28, 2021·Environmental Research·Gim Pao LimKian Sek Tee
Jul 14, 2021·Macromolecular Rapid Communications·Shaoshuai HeJunjie Li
Jul 24, 2021·Biomaterials Science·Xiangping LinTongkai Chen
Jul 1, 2021·ACS Sustainable Chemistry & Engineering·Agnieszka M Jastrzębska, Alexey S Vasilchenko
Jun 17, 2020·ACS Nano·Seunghyun HongHusam N Alshareef
Dec 9, 2019·ACS Biomaterials Science & Engineering·Błażej ScheibeŁucja Przysiecka
Dec 31, 2021·ACS Biomaterials Science & Engineering·Mahsa EbrahimiOmid Akhavan

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