2H,3H-decafluoropentane-based nanodroplets: new perspectives for oxygen delivery to hypoxic cutaneous tissues

PloS One
Mauro PratoCaterina Guiot

Abstract

Perfluoropentane (PFP)-based oxygen-loaded nanobubbles (OLNBs) were previously proposed as adjuvant therapeutic tools for pathologies of different etiology sharing hypoxia as a common feature, including cancer, infection, and autoimmunity. Here we introduce a new platform of oxygen nanocarriers, based on 2H,3H-decafluoropentane (DFP) as core fluorocarbon. These new nanocarriers have been named oxygen-loaded nanodroplets (OLNDs) since DFP is liquid at body temperature, unlike gaseous PFP. Dextran-shelled OLNDs, available either in liquid or gel formulations, display spherical morphology, ~600 nm diameters, anionic charge, good oxygen carrying capacity, and no toxic effects on human keratinocytes after cell internalization. In vitro OLNDs result more effective in releasing oxygen to hypoxic environments than former OLNBs, as demonstrated by analysis through oxymetry. In vivo, OLNDs effectively enhance oxy-hemoglobin levels, as emerged from investigation by photoacoustic imaging. Interestingly, ultrasound (US) treatment further improves transdermal oxygen release from OLNDs. Taken together, these data suggest that US-activated, DFP-based OLNDs might be innovative, suitable and cost-effective devices to topically treat hypoxia-asso...Continue Reading

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Citations

Jan 16, 2016·Therapeutic Delivery·Roberta CavalliMonica Argenziano
Jan 10, 2018·International Wound Journal·Lohrasb R SayadiAlan D Widgerow
Feb 28, 2019·Journal of Drug Targeting·Pravin Shende, Sajal Jain
Oct 2, 2019·Frontiers in Pharmacology·Sara ZullinoCaterina Guiot
Jun 14, 2021·Advances in Colloid and Interface Science·Marie Pierre Krafft, Jean G Riess
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shoeb Anwar AnsariCaterina Guiot
Oct 17, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Dimitrios P NtentakisNicolas Kalogerakis

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Methods Mentioned

BETA
rheometry
confocal microscopy
electron paramagnetic resonance
electron microscopy
optical microscopy
dynamic light scattering
light scattering
polarizing microscopy

Software Mentioned

SPSS
Fig

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