(2S)-7,4'-dihydroxy-8-prenylflavan stimulates adipogenesis and glucose uptake through p38MAPK pathway in 3T3-L1 cells

Biochemical and Biophysical Research Communications
Jun JiHeyao Wang

Abstract

Adipose tissue plays a key role in the development of obesity and diabetes. Natural products are one of the main sources for discovering new lead compounds. In the present study, (2S)-7,4'-dihydroxy-8-prenylflavan (DHPF), a natural prenylated flavan isolated from Morus yunnanensis, was found to significantly promote adipogenesis and increase glucose uptake in 3T3-L1 cells. Real-time PCR results showed that DHPF increased the expression of glucose and lipid metabolism-related genes (C/EBPα, PPARγ, aP2, GLUT4 and adiponectin) and decreased the expression of inflammatory cytokine TNF-α. Western blotting further revealed that DHPF activated p38 MAPK at the initial stage of 3T3-L1 preadipocyte differentiation. DHPF-induced activation of p38, adipogenesis and glucose uptake were effectively blocked by SB203580, a specific p38 inhibitor. These results indicate that DHPF could stimulate adipogenesis and increase glucose uptake through the p38 MAPK pathway, and DHPF may be useful for the prevention and treatment of obesity-associated disorders such as type 2 diabetes (T2D).

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Citations

May 21, 2016·Frontiers in Cell and Developmental Biology·Eddie Rodríguez-CarballoFrancesc Ventura
Jun 16, 2018·International Journal of Molecular Sciences·Ayumu TakenoToshitsugu Sugimoto
Jul 23, 2016·Molecular and Cellular Biochemistry·Luoyan AiZhuping Fan
Dec 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Motohiko UkiyaAtsuyoshi Nishina
Jul 25, 2019·Journal of Agricultural and Food Chemistry·Peng SunHe-Yao Wang

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