3-((+-)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) and phencyclidine produce a deficit of passive avoidance retention in rats

European Journal of Pharmacology
V J DeNobleL M Bauerle

Abstract

3-((+-)-2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), phencyclidine (PCP) and diazepam were evaluated for their ability to produce a deficit for a single trial step-through passive avoidance response in rats. Pretraining administration with CPP at doses ranging from 2.0 to 10.0 mg/kg s.c. significantly decreased retention latencies 24 h after passive avoidance training. Similar effects were found with PCP at doses ranging from 0.5 to 1.7 mg/kg s.c. and diazepam at doses between 5.0-18.0 mg/kg s.c. Pretraining administration with the benzodiazepine antagonist, RO15-1788 at doses between 0.1-15 mg/kg s.c., did not alter retention latencies. Co-administration of RO15-1788 (0.01-15.0 mg/kg s.c.) with CPP (6.0 mg/kg s.c.) or PCP (1.0 mg/kg s.c.) failed to block decreases in latencies. However, when RO15-1788 was co-administered with diazepam (9.0 mg/kg s.c.) a dose-related antagonism of diazepam's effects were found. These results suggest that the behavioral actions of CPP and PCP on passive avoidance retention are not mediated via the benzodiazepine receptor complex.

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Citations

Apr 10, 1990·European Journal of Pharmacology·K W JonesV J DeNoble
Nov 3, 1994·European Journal of Pharmacology·A BespalovE Zvartau
Sep 5, 1995·European Journal of Pharmacology·T MauriceS Lemaire
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·R Lalonde, C C Joyal
Oct 1, 1993·Pharmacology, Biochemistry, and Behavior·G R WengerD W Wright
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau

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