β3-Adrenergic Regulation of EPC Features Through Manipulation of the Bone Marrow MSC Niche

Journal of Cellular Biochemistry
Rana VafaeiVahid Siavashi

Abstract

Mesenchymal stem cells (MSCs) reside in a specific niche in the bone marrow, however, biological features of this niche are still not fully understood. Given the interactions of MSCs with endothelial cells in different tissues, bone marrow MSC niche may influence the biological features of endothelial progenitor cells (EPCs). To understand the role of the sympathetic nervous system in regulation of the MSC niche, we examined whether the manipulation of the MSC niche via β3-adrenergic signals will affect EPC features. A selective β3 agonist (BRL37344) or a β3 antagonist (SR59230A) was administered in mice for 2 weeks to determine the potential effects of these regimens on the population of CD133+ stem cells in the bone marrow. Then, bone marrow-derived MSCs and EPCs were harvested and expanded from the mice to examine the effect of changes in the MSC niche on EPC features. Improved MSC colony forming potency with increased bone marrow stromal cell-derived factor 1 (SDF-1) (also known as C-X-C motif chemokine 12 [CXCL12]) expression was shown as a result of intensification of the bone marrow adrenergic signals through BRL37344 injection. On the other hand, the blockage of these signals limited the expression level of SDF-1 and re...Continue Reading

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Citations

Nov 1, 2018·Journal of Cellular Biochemistry·Simin AsadianSeyed Mahdi Nassiri
Nov 20, 2017·Tissue Engineering and Regenerative Medicine·Ji Eun Lim, Youngsook Son
Apr 22, 2020·Inhalation Toxicology·Vahid SiavashiTooba Ghazanfari
Dec 7, 2018·Biochimica Et Biophysica Acta. Molecular Cell Research·Samaneh KeshavarzNika Sadat Alimi
Jun 28, 2021·Cellular & Molecular Biology Letters·Shabnam BabazadehMohamad Zamani-Ahmadmahmudi

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