β3-Adrenoceptor-mediated responses in diabetic rat heart

General Physiology and Biophysics
Gizem Kayki-MutluVecdi Melih Altan

Abstract

β3-adrenoceptors mediate negative inotropic effect in contrast to classical β1- and β2-adrenoceptors. Cardiac β3-adrenoceptors are upregulated in experimental diabetes. Thus, cardiodepressant effect mediated by β3-adrenoceptors has been proposed to contribute to the impaired cardiac function in this pathology. In our study, we investigated the influence of streptozotocin-diabetes on cardiac contractility to β3-adrenoceptors stimulation by using Langendorff-perfused rat hearts. BRL 37344, a selective β3-adrenoceptor agonist, induced dose-dependent decreases in left ventricular developed pressure (LVDP) in hearts from control rats. BRL 37344 also dose-dependently decreased +dP/dt and -dP/dt values. Effects of BRL 37344 were abolished by SR 59230, but not altered by nadolol pre-treatment. On the other hand, these effects of BRL 37344 were all significantly increased in hearts from diabetic rats. We also observed that diabetes significantly increased the mRNA levels encoding cardiac β3-adrenoceptors. In addition, Giα2 mRNA expressions were found to be increased in the cardiac tissue of diabetic rats as well. The effect of BRL 37344 on cardiac contractility was normalized upon treatment of diabetic rats with insulin. These data demo...Continue Reading

Citations

Feb 28, 2019·British Journal of Pharmacology·Katerina OkekeMartin C Michel
Feb 26, 2019·British Journal of Pharmacology·Ebru Arioglu-InanMartin C Michel
Jan 25, 2018·Molecular and Cellular Biochemistry·Gizem Kayki MutluAntonio Zaza
Dec 20, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Massimo Dal MonteMartin C Michel
Dec 2, 2020·Cells·Betul R ErdoganEbru Arioglu-Inan

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