3-Amino-4-aminoximidofurazan derivatives: small molecules possessing antimicrobial and antibiofilm activity against Staphylococcus aureus and Pseudomonas aeruginosa

Journal of Applied Microbiology
M C DasS Bhattacharjee

Abstract

The therapeutic treatment of microbial infections involving biofilm becomes quite challenging because of its increasing antibiotic resistance capacities. Towards this direction, in the present study we have evaluated the antibiofilm property of synthesized 3-amino-4-aminoximidofurazan compounds having polyamine skeleton. These derivatives were synthesized by incorporating furazan and biguanide moieties. Different 3-amino-4-aminoximidofurazan derivatives (PI1-4) were synthesized via protic acid catalysis and subsequently characterized by (1) H NMR and (13) C NMR spectra, recorded at 400 and 100 MHz respectively. We have tested the antimicrobial and antibiofilm activities of these synthetic derivatives (PI1-4) against both Staphylococcus aureus and Pseudomonas aeruginosa. The compounds so tested were also compared with standard antibiotics namely Tobramycin (Ps. aeruginosa) and Azithromycin (Staph. aureus) which were used as a positive control in all experimental sets. All these compounds (PI1-4) exhibited moderate to significant antimicrobial activities against both micro-organisms wherein compound PI3 showed maximum activity. Biofilm inhibition of both micro-organisms was then evaluated by crystal violet and safranin staining, ...Continue Reading

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Citations

Nov 9, 2018·World Journal of Microbiology & Biotechnology·Tapas DasUtpal Ch De
Nov 27, 2019·Applied Microbiology and Biotechnology·Fazlurrahman KhanYoung-Mog Kim
Sep 11, 2017·Antonie van Leeuwenhoek·Purnita BhattacharyyaProsun Tribedi
Jan 14, 2021·Molecular Diversity·Sukhen BhowmikUtpal C De
Feb 12, 2021·Journal of Medicinal Chemistry·Ross S ManciniMark A Reed

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