3-D imaging and illustration of the perfusive mouse islet sympathetic innervation and its remodelling in injury.

Y-C ChiuS-C Tang


Sympathetic nerves influence islet hormone levels in the circulation. Insights into islet sympathetic innervation and its remodelling in diabetes may impact future therapeutics. However, standard immunohistochemistry and microtome-based microscopy cannot provide an integral view of the islet neurovascular complex. We prepared transparent islet specimens to investigate the spatial relationship between sympathetic nerves, blood vessels and islet cells in normal, streptozotocin-injected and non-obese diabetic mouse models. Cardiac perfusion of fluorescent lectin was used to label pancreatic blood vessels. Tyrosine hydroxylase and nuclear staining were used to reveal islet sympathetic innervation and microstructure. Optical clearing (i.e. use of immersion solution to reduce scattering) was applied to enable 3-dimensional confocal microscopy of islets to visualise the sympathetic neurovascular complex in space. Unlike previously reported morphology, we observed perfusive intra-islet, perivascular sympathetic innervation, in addition to peri-islet contacts of sympathetic nerves with alpha cells and sympathetic fibres encircling the adjacent arterioles. The intra-islet axons became markedly prominent in streptozotocin-injected mice (2...Continue Reading


Jul 1, 1974·Physiological Reviews·S C Woods, D Porte
Jan 20, 2004·The Journal of Comparative Neurology·John L MignoneGrigori Enikolopov
Aug 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Maria C DenisRalph Weissleder
Aug 13, 2005·Microvascular Research·Dino J RavnicMoritz A Konerding
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Over CabreraAlejandro Caicedo
Mar 28, 2006·Experimental Biology and Medicine·Maria Elena LarrietaMarcia Hiriart
Jan 31, 2007·Endocrine Reviews·Jesper GromadaClaes B Wollheim
Aug 9, 2007·The Journal of Clinical Endocrinology and Metabolism·Lisa K GilliamGerald J Taborsky
Nov 14, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·David A Taylor-FishwickAaron I Vinik
Nov 17, 2007·Neuroscience·R E Burris, M Hebrok
May 10, 2008·Journal of Biomedical Optics·Valery V TuchinAlvin T Yeh
Aug 24, 2010·Gastroenterology·Ya-Yuan Fu, Shiue-Cheng Tang
Jul 5, 2011·Cell Metabolism·Gerald J Taborsky
Jul 5, 2011·Cell Metabolism·Rayner Rodriguez-DiazAlejandro Caicedo
Sep 8, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-A LiuS-C Tang
Oct 6, 2011·Nature Reviews. Gastroenterology & Hepatology·Katherine Smith
Mar 17, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuan-An LiuShiue-Cheng Tang

❮ Previous
Next ❯


Jun 27, 2013·Diabetologia·Shiue-Cheng TangYa-Yuan Fu
Aug 1, 2013·Biochemical and Biophysical Research Communications·Mami NakamuraTadahide Furuno
Sep 27, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Rayner Rodriguez-Diaz, Alejandro Caicedo
Sep 24, 2013·Metabolism: Clinical and Experimental·Ryuichi SakamotoRyoichi Takayanagi
Sep 10, 2014·Diabetes, Obesity & Metabolism·S-C TangH-J Chien
Sep 10, 2014·Diabetes, Obesity & Metabolism·B Thorens
Oct 27, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H-J ChienS-C Tang
Mar 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y A LiuS C Tang
Dec 21, 2013·Acta Physiologica·B Hellman, E Grapengiesser
Jan 28, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·I GiannulisS Cinti
May 5, 2012·PloS One·Carlus DenekeAngelo Valleriani
Jun 25, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pei-Yu LinShiue-Cheng Tang
Sep 3, 2017·Diabetologia·Shiue-Cheng TangPankaj J Pasricha
Feb 15, 2019·Biology·Magdalena BlaszkiewiczKristy L Townsend
Jan 16, 2014·American Journal of Physiology. Endocrinology and Metabolism·Jyuhn-Huarng JuangShiue-Cheng Tang
Aug 31, 2017·Diabetologia·Shiue-Cheng TangMichael S German
Sep 30, 2018·Current Diabetes Reports·Shiue-Cheng TangMartha Campbell-Thompson
Oct 3, 2020·Chaos·M BarreraC Villarreal
Jan 11, 2020·Endocrinology, Diabetes & Metabolism·Marie-Béatrice SaadeSophie Blat
Oct 11, 2020·Science Advances·Alexandra AlvarssonSarah A Stanley
Nov 25, 2020·Trends in Neurosciences·Eugene E LinRejji Kuruvilla
Mar 24, 2021·Scientific Reports·Martha Campbell-ThompsonMark A Atkinson
May 14, 2021·Frontiers in Endocrinology·Martha Campbell-Thompson, Shiue-Cheng Tang
Oct 12, 2017·Biochimie·Luc Pénicaud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.