3-D Imaging Reveals Participation of Donor Islet Schwann Cells and Pericytes in Islet Transplantation and Graft Neurovascular Regeneration

EBioMedicine
Jyuhn-Huarng JuangShiue-Cheng Tang

Abstract

The primary cells that participate in islet transplantation are the endocrine cells. However, in the islet microenvironment, the endocrine cells are closely associated with the neurovascular tissues consisting of the Schwann cells and pericytes, which form sheaths/barriers at the islet exterior and interior borders. The two cell types have shown their plasticity in islet injury, but their roles in transplantation remain unclear. In this research, we applied 3-dimensional neurovascular histology with cell tracing to reveal the participation of Schwann cells and pericytes in mouse islet transplantation. Longitudinal studies of the grafts under the kidney capsule identify that the donor Schwann cells and pericytes re-associate with the engrafted islets at the peri-graft and perivascular domains, respectively, indicating their adaptability in transplantation. Based on the morphological proximity and cellular reactivity, we propose that the new islet microenvironment should include the peri-graft Schwann cell sheath and perivascular pericytes as an integral part of the new tissue.

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Citations

Oct 27, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H-J ChienS-C Tang
Jul 3, 2015·EBioMedicine·Julia Y S Tsang, Gary M K Tse
Apr 29, 2016·Upsala Journal of Medical Sciences·Leif JanssonPer-Ola Carlsson
Jun 25, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pei-Yu LinShiue-Cheng Tang
Sep 3, 2017·Diabetologia·Shiue-Cheng TangPankaj J Pasricha
Apr 3, 2020·Journal of Molecular Cell Biology·Jinglong Guo, Wenxian Fu
Sep 30, 2018·Current Diabetes Reports·Shiue-Cheng TangMartha Campbell-Thompson
Mar 22, 2019·Cell Communication and Signaling : CCS·Mohammad Hossein GeranmayehMehdi Farhoudi
Oct 13, 2017·Journal of Biophotonics·Tingting YuDan Zhu
Oct 11, 2020·Science Advances·Alexandra AlvarssonSarah A Stanley
May 14, 2021·Frontiers in Endocrinology·Martha Campbell-Thompson, Shiue-Cheng Tang

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Methods Mentioned

BETA
transgenic
confocal microscopy
feature extraction
light scattering
flow microscopy
super-resolution microscopy
light

Software Mentioned

LSM
Avizo

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