The primary cells that participate in islet transplantation are the endocrine cells. However, in the islet microenvironment, the endocrine cells are closely associated with the neurovascular tissues consisting of the Schwann cells and pericytes, which form sheaths/barriers at the islet exterior and interior borders. The two cell types have shown their plasticity in islet injury, but their roles in transplantation remain unclear. In this research, we applied 3-dimensional neurovascular histology with cell tracing to reveal the participation of Schwann cells and pericytes in mouse islet transplantation. Longitudinal studies of the grafts under the kidney capsule identify that the donor Schwann cells and pericytes re-associate with the engrafted islets at the peri-graft and perivascular domains, respectively, indicating their adaptability in transplantation. Based on the morphological proximity and cellular reactivity, we propose that the new islet microenvironment should include the peri-graft Schwann cell sheath and perivascular pericytes as an integral part of the new tissue.
Ultrastructural evidence for the presence of a glial sheath investing the islets of Langerhans in the pancreas of mammals
Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury
Islet injury induces neurotrophin expression in pancreatic cells and reactive gliosis of peri-islet Schwann cells
Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells
Role of central nervous system microvascular pericytes in activation of antigen-primed splenic T-lymphocytes
Optical clearing of in vivo human skin: implications for light-based diagnostic imaging and therapeutics
Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome
Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts
Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function
Glial cell line-derived neurotrophic factor increases beta-cell mass and improves glucose tolerance.
Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in the HIP rat model of diabetes.
Microtome-free 3-dimensional confocal imaging method for visualization of mouse intestine with subcellular-level resolution.
The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action.
Unexpected acceleration of type 1 diabetes by transgenic expression of B7-H1 in NOD mouse peri-islet glia.
Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution
3-D imaging and illustration of the perfusive mouse islet sympathetic innervation and its remodelling in injury.
SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction
Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation
Three-dimensional islet graft histology: panoramic imaging of neural plasticity in sympathetic reinnervation of transplanted islets under the kidney capsule
3-D imaging of islets in obesity: formation of the islet-duct complex and neurovascular remodeling in young hyperphagic mice
PanIN-associated pericyte, glial, and islet remodeling in mice revealed by 3D pancreatic duct lesion histology
Nerve/glial antigen 2 is crucially involved in the revascularization of freely transplanted pancreatic islets
Autonomic reinnervation and functional regeneration in autologous transplanted submandibular glands in patients with severe keratoconjunctivitis sicca
Recruited fibroblasts reconstitute the peri-islet membrane: a longitudinal imaging study of human islet grafting and revascularisation
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