PMID: 11324913Apr 28, 2001Paper

3-Desoxyanthocyanidins from Arrabidaea chica

Phytochemistry
B ZornI Merfort

Abstract

The new 3-desoxyanthocyanidins 6,7,3'-trihydroxy-5,4'-dimethoxy-flavylium and 6,7,3',4'-tetrahydroxy-5-methoxy-flavylium and the known 6,7-dihydroxy-5,4'-dimethoxy-flavylium (Carajurin) were isolated by bioguided fractionation from the leaves of Arrabidaea chica, with transcription factor NF-kappaB as target. The structure of Carajurone was revised to be 6,7,4'-trihydroxy-5-methoxy-flavylium. Additionally, the flavone acacetin was found. All structures were mainly established on the basis of MS- and NMR data (1H, 1H-1H COSY and partly 13C, GHMQCR and GHSQCR). Carajurin, which failed to give a positive result in the DPPH TLC assay completely inhibited NF-kappaB, but not NF-AT at a 500 microM concentration.

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Citations

Apr 6, 2013·Journal of Toxicology and Environmental Health. Part a·Vinícius Carlotto dos SantosJaqueline Nascimento Picada
Sep 7, 2013·PloS One·Jackeline Tiemy Guinoza SiraichiDiógenes Aparício Garcia Cortez
Jul 21, 2011·Pharmacognosy Research·Benedito Junior Lima de MedeirosJosé Carlos Tavares Carvalho
May 6, 2009·Biological Trace Element Research·Igor Rafael dos Santos MagalhãesMaria Rosa Lozano Borrás
Feb 17, 2015·Journal of Ethnopharmacology·Ana Flávia Ribeiro Machado MichelElaine Maria Souza-Fagundes
Jan 6, 2016·BMC Complementary and Alternative Medicine·Joicy Cortez de SáAna Lucia Abreu-Silva
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Sep 28, 2013·Journal of Ethnopharmacology·Luciano MafioletiDomingos Tabajara de Oliveira Martins
Aug 16, 2011·Chemical Society Reviews·Fernando PinaJoão C Lima
Sep 25, 2019·International Journal of Molecular Sciences·Cleydlenne Costa VasconcelosMaria do Socorro de Sousa Cartágenes
Aug 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carla Junqueira Moragas-TellisMaria Dutra Behrens
Dec 12, 2019·Acta Cirúrgica Brasileira·Keyla Borges Ferreira RochaAldo Cunha Medeiros
Sep 1, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shilpi SinghSuaib Luqman
Sep 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Yun XiongZhongxiang Fang
Feb 25, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jesus Olivero-VerbelElena Stashenko
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·João Victor Silva-SilvaKátia S Calabrese
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Oct 25, 2003·Journal of Natural Products·Patrícia Mendonça PaulettiVanderlan da Silva Bolzani

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