3-indolylacetonitrile decreases Escherichia coli O157:H7 biofilm formation and Pseudomonas aeruginosa virulence

Environmental Microbiology
Jin-Hyung LeeJintae Lee

Abstract

Intercellular signal indole and its derivative hydroxyindoles inhibit Escherichia coli biofilm and diminish Pseudomonas aeruginosa virulence. However, indole and bacterial indole derivatives are unstable in the microbial community because they are quickly degraded by diverse bacterial oxygenases. Hence, this work sought to identify novel, non-toxic, stable and potent indole derivatives from plant sources for inhibiting the biofilm formation of E. coli O157:H7 and P. aeruginosa. Here, plant auxin 3-indolylacetonitrile (IAN) was found to inhibit the biofilm formation of both E. coli O157:H7 and P. aeruginosa without affecting its growth. IAN more effectively inhibited biofilms than indole for the two pathogenic bacteria. Additionally, IAN decreased the production of virulence factors including 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS), pyocyanin and pyoverdine in P. aeruginosa. DNA microarray analysis indicated that IAN repressed genes involved in curli formation and glycerol metabolism, whereas IAN induced indole-related genes and prophage genes in E. coli O157:H7. It appeared that IAN inhibited the biofilm formation of E. coli by reducing curli formation and inducing indole production. Also, corroborating phenotypic results of P...Continue Reading

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Citations

Jan 26, 2012·Applied Microbiology and Biotechnology·Jin-Hyung LeeJintae Lee
Jun 23, 2012·Applied Microbiology and Biotechnology·Yong-Guy KimJintae Lee
Jan 16, 2013·Applied Microbiology and Biotechnology·Jin-Hyung LeeJintae Lee
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May 31, 2011·BMC Microbiology·Yong-Guy KimJintae Lee
Jan 25, 2014·International Journal of Food Microbiology·Jin-Hyung LeeJintae Lee
Jul 10, 2014·Foodborne Pathogens and Disease·Kayeon LeeJintae Lee
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Aug 30, 2016·Indian Journal of Microbiology·Minsu KimJintae Lee
Oct 7, 2015·Trends in Microbiology·Jin-Hyung LeeJintae Lee
Dec 17, 2014·International Journal of Food Microbiology·Yong-Guy KimJintae Lee
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