3 Tesla 23 Na Magnetic Resonance Imaging During Acute Kidney Injury

Academic Radiology
Matthias HammonAnke Dahlmann

Abstract

Sodium and proton magnetic resonance imaging (23Na/1H-MRI) have shown that muscle and skin can store Na+ without water. In chronic renal failure and in heart failure, Na+ mobilization occurs, but is variable depending on age, dialysis vintage, and other features. Na+ storage depots have not been studied in patients with acute kidney injury (AKI). We studied 7 patients with AKI (mean age: 51.7 years; range: 25-84) and 14 age-matched and gender-matched healthy controls. All underwent 23Na/1H-MRI at the calf. Patients were studied before and after acute hemodialysis therapy within 5-6 days. The 23Na-MRI produced grayscale images containing Na+ phantoms, which served to quantify Na+ contents. A fat-suppressed inversion recovery sequence was used to quantify H2O content. Plasma Na+ levels did not change. Mean Na+ contents in muscle and skin did not significantly change following four to five cycles of hemodialysis treatment (before therapy: 32.7 ± 6.9 and 44.2 ± 13.5 mmol/L, respectively; after dialysis: 31.7 ± 10.2 and 42.8 ± 11.8 mmol/L, respectively; P > .05). Water content measurements did not differ significantly before and after hemodialysis in muscle and skin (P > .05). Na+ contents in calf muscle and skin of patients before ...Continue Reading

References

Apr 29, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S KrautzigS Shaldon
Jul 31, 2003·American Journal of Physiology. Renal Physiology·Jens TitzeKarl F Hilgers
Dec 1, 1957·The Journal of Clinical Investigation·S J FARBERN SCHUSTER
Aug 1, 1959·The American Journal of Medicine·I S EDELMAN, J LEIBMAN
May 1, 1960·Circulation·S J FARBER
Jul 1, 1955·The Journal of Clinical Investigation·W H BERGSTROM
Feb 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jens TitzeKarl F Hilgers
May 26, 2005·American Journal of Physiology. Renal Physiology·Jens TitzeKarl F Hilgers
May 4, 2006·Nephrology·Nabieh Al-HilaliKaivilayil V Johny
Jun 16, 2006·Radiology·Marc-André WeberHans-Michael Meinck
Jan 25, 2007·American Journal of Physiology. Renal Physiology·Markus SchafflhuberJens Titze
Jan 30, 2007·Breast Cancer Research and Treatment·Ronald OuwerkerkPaul A Bottomley
Nov 14, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Meral KayikciogluErcan Ok
Oct 28, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Armin M NagelLothar R Schad
Mar 24, 2010·European Radiology·Gregory ChangRavinder R Regatte
Oct 26, 2011·Circulation·Edward D Frohlich, Dinko Susic
Dec 8, 2011·Hypertension·Christoph KoppJens Titze
Dec 4, 2012·Kidney International·Christoph KoppJens Titze
Feb 19, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ender HurErcan Ok
Mar 8, 2013·Nature·Markus KleinewietfeldDavid A Hafler
Mar 29, 2013·The New England Journal of Medicine·Theodore A KotchenEdward D Frohlich
Jun 1, 2013·The Journal of Clinical Investigation·Helge WiigJens Titze
May 13, 2014·Progress in Nuclear Magnetic Resonance Spectroscopy·Guillaume MadelinAlexej Jerschow
Aug 8, 2014·Kidney International·Anke DahlmannJens M Titze
Feb 17, 2015·NMR in Biomedicine·Paul A Bottomley
Feb 6, 2017·Journal of the American Society of Nephrology : JASN·Markus P SchneiderKai-Uwe Eckardt

❮ Previous
Next ❯

Citations

Nov 27, 2019·Journal of Clinical Medicine·Sophie RothMarcus Kelm
Sep 7, 2017·Current Opinion in Nephrology and Hypertension·Susan FrancisMaarten W Taal
Sep 2, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lena V GastArmin M Nagel
Aug 1, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rik H G Olde EngberinkLiffert Vogt
Jun 27, 2019·Nature Reviews. Nephrology·Nicola WilckDominik N Müller
Nov 30, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Róbert AgócsAttila J Szabó
Jan 12, 2019·F1000Research·Joshua Thurman, Faikah Gueler
Aug 3, 2020·Journal of Hypertension·Julie KolwelterRoland E Schmieder
May 27, 2021·The Journal of Clinical Endocrinology and Metabolism·Lia PuderMarcus Kelm
Dec 1, 2021·The Journal of Clinical Hypertension·Zhiyi MaYuanyuan Chen
Dec 18, 2021·Journal of Magnetic Resonance Imaging : JMRI·Qingping ChenWieland A Worthoff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.