3-year actuarial biochemical recurrence-free survival following laparoscopic radical prostatectomy: experience from a tertiary referral center in the United States

The Journal of Urology
Christian P PavlovichL i-Ming Su

Abstract

We performed a prospective analysis of pathological and oncological outcomes following laparoscopic radical prostatectomy at a medical center in the United States. A total of 528 men underwent laparoscopic radical prostatectomy between April 2001 and August 2005. We excluded 4 open surgical conversions (0.8%) and 16 men (3.0%) without followup. The remaining 508 men had a mean preoperative prostate specific antigen of 6.0 ng/ml (range 0.3 to 27) and Gleason score of 6.3 (range 6 to 10). Stage was cT1b in 1 case (0.2%), cT1c in 350 (68.9%), cT2a in 135 (26.6%), cT2b in 21 (4.1%) and cT2c in 1 (0.2%). Of the patients 89% underwent cavernous nerve preservation. Biochemical recurrence was defined and timed at the first prostate specific antigen of 0.2 ng/ml or greater if at repeat testing it remained 0.2 ng/ml or greater. Mean followup was 13.2 months (median 12, range 2 to 52). Pathological stage was pT0N0/Nx in 2 men (0.4%), pT2N0/Nx in 414 (81.5%), pT3aN0/Nx in 72 (14.2%), pT3bN0/Nx in 17 (3.3%) and pT2-3N1 in 3 (0.6%). Positive margin rates increased with higher stage (8.2% in pT2 and 39.3% in pT3 cases, p <0.0001). Three-year actuarial biochemical recurrence-free survival was 98.2% for pT2N0/Nx and 78.7% for pT3N0/Nx/N1 diseas...Continue Reading

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Citations

Apr 25, 2012·Der Urologe. Ausg. A·H M DoJ-U Stolzenburg
Jan 16, 2013·JSLS : Journal of the Society of Laparoendoscopic Surgeons·Serge GinzburgJoseph R Wagner
Nov 20, 2012·Surgical Oncology Clinics of North America·Gurdarshan S SandhuGerald L Andriole
Apr 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Valérie FonteyneGert De Meerleer
Mar 17, 2009·Surgical Oncology·Trinity J BivalacquaLi-Ming Su
Nov 18, 2008·European Urology·Karim TouijerBertrand Guillonneau
Sep 2, 2008·The Urologic Clinics of North America·Mark L GonzalgoVipul R Patel
Aug 8, 2014·BJU International·Ricardo SoaresChristopher G Eden
May 5, 2009·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Pierluigi BoveGiuseppe Vespasiani
Oct 8, 2017·European Radiology·Lars A R ReisæterChristian Beisland

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