30 Gy single dose stereotactic body radiation therapy (SBRT): Report on outcome in a large series of patients with lung oligometastatic disease.

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Mattia Falchetto OstiLuca Nicosia

Abstract

To evaluate the local control (LC) and long term adverse effects in a series of patients with lung metastases who received 30 Gy in single dose with stereotactic technique. Between December 2008 and April 2016, a total of 166 lung metastases in 129 patients affected by oligometastatic disease were treated at our Institution with stereotactic body radiotherapy (SBRT). Mainly, the primary tumors were non small-cell lung cancer and colorectal cancer (45.2% and 28.8%, respectively). Prognostic factors were also assessed. The median follow-up was 38 months. Local progression occurred in 24 (14.4%) lesions in 21 patients. Intra-thoracic progression (new lung lesions or thoracic lymph node metastases) occurred in 59 (45.7%) patients. Forty-five (34.8%) patients had distant progression after a median time of 14 months. The 3- and 5-years local relapse-free survival (LPFS) were 80.1% and 79.2% (median not reached), respectively. One-hundred forty-eight patients were evaluated for late toxicity (follow-up >6 months): 51 (34.4%) patients had grade ≤2 fibrosis, 11 (7.4%) patients experienced grade 3 fibrosis. Two (1.3%) cases of rib fracture occurred. One case of toxic death (grade 5) has been reported. Median OS was 39 months. At the univ...Continue Reading

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Citations

May 14, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Luca NicosiaFilippo Alongi
May 2, 2020·Journal of Cancer Research and Clinical Oncology·Luca NicosiaFilippo Alongi
Aug 21, 2019·Cancer Research·Katherine D Castle, David G Kirsch
Apr 12, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F AlongiM F Osti
Jul 17, 2021·Journal of Cancer Research and Clinical Oncology·Francesco CucciaFilippo Alongi
Sep 7, 2021·Clinical & Experimental Metastasis·Francesco CucciaFilippo Alongi
Sep 11, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·I F Remmerts de VriesWilko Verbakel
Nov 9, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·L NicosiaF Alongi

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