PMID: 11920514Mar 29, 2002Paper

31Phosphorus-magnetic resonance spectroscopy to assess histologic tumor response noninvasively after isolated limb perfusion for soft tissue tumors

Cancer
Christoph KettelhackP Hohenberger

Abstract

In patients with unresectable soft tissue sarcoma of the extremities, isolated limb perfusion (ILP) has been reported to result in significant tumor regression enabling limb-sparing resection in the majority of patients. However, clinical tumor response as evaluated by imaging and histopathology (extent of tumor necrosis) often differ significantly. The current study was initiated to evaluate prospectively the role of 31phosphorus-magnetic resonance spectroscopy (31P-MRS) in the noninvasive assessment of histologic response in patients treated with ILP. Thirty-two patients with locally advanced and unresectable soft tissue tumors (sarcoma in 28 patients and bulky melanoma in 4 patients) were treated by ILP with recombinant human tumor necrosis factor-alpha and melphalan or with cytostatics. 31P-MRS was performed prior to treatment and at regular intervals after ILP until definite tumor resection. Clinical response parameters according to the World Health Organization as well as the histopathologic necrosis rate of the resection specimen were correlated with changes in the energy-rich phosphorous metabolites phosphocreatine (PCR); alpha-, beta-, gamma-adenosine triphosphate (ATP); phosphomonoesters (PME); and inorganic phosphate...Continue Reading

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Citations

Sep 13, 2002·NMR in Biomedicine
Sep 16, 2004·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·P-U TunnP M Schlag
Jan 18, 2006·European Radiology·Hervé BrisseSylvia Neuenschwander
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Nov 9, 2006·Archives of Pathology & Laboratory Medicine·Jean-Michel Coindre

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